Cell adhesion articles within Nature Medicine

Featured

  • Article |

    Hosen et al. identify an active conformation of integrin beta-7 as a cancer-associated antigen in multiple myeloma, and engineer a CAR-T cell that shows efficacy against MM in a mouse model. These findings describe the first conformation-specific CAR-T cell and highlight the potential of conformational targets in cancer immunotherapy.

    • Naoki Hosen
    • , Yukiko Matsunaga
    •  & Atsushi Kumanogoh

  • Article |

    Mutations in Kindlin-1 result in Kindler syndrome, which is marked by skin blistering, premature skin aging and increased risk for skin cancer. Reinhard Fässler and his colleagues have developed a new mouse model of the condition, revealing new cellular and molecular mechanistic insight into the pathology of the syndrome.

    • Emanuel Rognoni
    • , Moritz Widmaier
    •  & Reinhard Fässler

  • News & Views |

    Cell-mediated activation of latent TGF-β1 is a key promoting event in fibrosis in all organs. A new study shows that specific targeting of the αv subunit of integrins in fibrogenic myofibroblasts effectively reduces developing and established fibrosis in liver, kidneys and lungs (pages 1617–1624).

    • Boris Hinz

  • Letter |

    A major issue in the clinic is excessive, or hypertrophic, scarring of the skin after injury. Geoffrey Gurtner and his colleagues have now shown that mechanical forces during such injury upregulates focal adhesion kinase (FAK), which in turn leads to the release of a cytokine that promotes inflammation and fibrosis. They also show that genetic deletion of FAK or its pharmacological inhibition results in minimal scarring in a mouse model.

    • Victor W Wong
    • , Kristine C Rustad
    •  & Geoffrey C Gurtner

  • Article |

    The miR200 family regulates EMT through E-cadherin modulation and has been proposed to contribute to metastasis thusly. This report identifies a promoting role of miR-200 in metastatic colonization that involves a novel target, the tumor secretome. The correlation between miR-200 and metastasis in people with cancer supports the relevance of this biphasic, multifaceted role of miR-200.

    • Manav Korpal
    • , Brian J Ell
    •  & Yibin Kang

  • Article |

    Inflammatory cell recruitment to injured tissues is needed for repair, but an excessive inflammatory response can exacerbate injury. Tibor Kempf et al. now identify the cytokine GDF-15 as a new anti-inflammatory factor that dampens leukocyte recruitment in the setting of myocardial infarction in mice, thereby preventing cardiac rupture. GDF-15 blocks leukocyte extravasation from the blood into injured tissue by inhibiting the activation of cell surface integrin receptors.

    • Tibor Kempf
    • , Alexander Zarbock
    •  & Kai C Wollert

  • Article |

    A subset of series B adenoviruses binds epithelial cells via a previously unknown receptor. Wang et al. now identify this receptor as desmoglein-2 (DSG-2), which has a role in intercellular adhesion. Binding of group B Ad3 to DSG-2 triggered an epithelial to mesenchymal transition, opened intercellular junctions and increased access to junction-localized proteins, which together may contribute to the spread of these viruses though epithelial tissues.

    • Hongjie Wang
    • , Zong-Yi Li
    •  & André Lieber

Browse broader subjects

Browse narrower subjects

Browse Cell adhesion across other nature.com journals