Cadherins articles within Nature Medicine

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• Article | 07 August 2011

  Direct targeting of Sec23a by miR-200s influences cancer cell secretome and promotes metastatic colonization

  The miR200 family regulates EMT through E-cadherin modulation and has been proposed to contribute to metastasis thusly. This report identifies a promoting role of miR-200 in metastatic colonization that involves a novel target, the tumor secretome. The correlation between miR-200 and metastasis in people with cancer supports the relevance of this biphasic, multifaceted role of miR-200.

  • Manav Korpal
  • , Brian J Ell
  •  & Yibin Kang

• Article | 12 December 2010

  Desmoglein 2 is a receptor for adenovirus serotypes 3, 7, 11 and 14

  A subset of series B adenoviruses binds epithelial cells via a previously unknown receptor. Wang et al. now identify this receptor as desmoglein-2 (DSG-2), which has a role in intercellular adhesion. Binding of group B Ad3 to DSG-2 triggered an epithelial to mesenchymal transition, opened intercellular junctions and increased access to junction-localized proteins, which together may contribute to the spread of these viruses though epithelial tissues.

  • Hongjie Wang
  • , Zong-Yi Li
  •  & André Lieber

• Article | 07 November 2010

  Monoclonal antibody targeting of N-cadherin inhibits prostate cancer growth, metastasis and castration resistance

  The transition from androgen-dependent to castration-resistant prostate cancer is a lethal event. N-cadherin seems to be a major cause underlying this transition, and targeting this adhesion molecule may have positive clinical benefit.

  • Hiroshi Tanaka
  • , Evelyn Kono
  •  & Robert E Reiter