Cytotoxic T cells articles within Nature

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• Article
  15 November 2023 | Open Access

  Single-cell CRISPR screens in vivo map T cell fate regulomes in cancer

  Analyses of causal gene regulatory networks have identified key checkpoints mediating the progressive differentiation of CD8⁺ cytotoxic T cells, findings that have implications for anticancer immunotherapies such as adoptive cell therapy and immune checkpoint blockade.

  • Peipei Zhou
  • , Hao Shi
  •  & Hongbo Chi

• Article | 01 September 2021

  Functional HPV-specific PD-1⁺ stem-like CD8 T cells in head and neck cancer

  An analysis of human papillomavirus (HPV)-specific CD8 T cells in patients with head and neck cancer identifies functional PD-1⁺TCF-1⁺CD8 T cells in the tumour with implications for therapeutic vaccination and PD-1 directed immunotherapy.

  • Christiane S. Eberhardt
  • , Haydn T. Kissick
  •  & Rafi Ahmed

• Article | 11 December 2019

  An intra-tumoral niche maintains and differentiates stem-like CD8 T cells

  The authors examine the immune cell infiltrates of human tumours and provide evidence for a population of CD8 T cells with stem-cell characteristics and proliferative capacity that reside in an antigen-presenting niche within tumours.

  • Caroline S. Jansen
  • , Nataliya Prokhnevska
  •  & Haydn Kissick

• Article | 11 December 2019

  Targeting REGNASE-1 programs long-lived effector T cells for cancer therapy

  CRISPR–Cas9 mutagenesis screenings reveal that targeting REGNASE-1 leads to improved therapeutic efficacy of CD8⁺ T cells against mouse models of cancer, and identify BATF as a key target of REGNASE-1.

  • Jun Wei
  • , Lingyun Long
  •  & Hongbo Chi

• Article | 02 October 2019

  Dynamics and genomic landscape of CD8⁺ T cells undergoing hepatic priming

  CD8⁺ T cells that are primed by hepatocytes differentiate into dysfunctional T cells, which can be rescued by treatment with IL-2.

  • Alexandre P. Bénéchet
  • , Giorgia De Simone
  •  & Matteo Iannacone

• Article | 26 October 2016

  S-2-hydroxyglutarate regulates CD8⁺ T-lymphocyte fate

  S-2-hydroxyglutarate produced by CD8+ T cells under hypoxic conditions affects locus-specific histone and DNA methylation patterns, which enhances T-cell proliferation, survival and recall responses.

  • Petros A. Tyrakis
  • , Asis Palazon
  •  & Randall S. Johnson

• Letter | 29 June 2015

  T-cell exhaustion, co-stimulation and clinical outcome in autoimmunity and infection

  CD8 T-cell exhaustion, although a negative prognostic indicator during persistent infections, is shown to be associated with a good outcome in autoimmune and inflammatory diseases.

  • Eoin F. McKinney
  • , James C. Lee
  •  & Kenneth G. C. Smith

• Letter | 10 October 2012

  Melanomas resist T-cell therapy through inflammation-induced reversible dedifferentiation

  A genetically engineered mouse model is used to determine the mechanism of acquired resistance to adoptive therapy with cytotoxic T cells specific for a melanocytic differentiation antigen; tumour necrosis factor (TNF)-α is identified as a crucial factor that causes reversible dedifferentiation of mouse and human melanoma cells.

  • Jennifer Landsberg
  • , Judith Kohlmeyer
  •  & Thomas Tüting