Featured
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| Open AccessInteractions between folate intake and genetic predictors of gene expression levels associated with colorectal cancer risk
- Cameron B. Haas
- , Yu-Ru Su
- & Li Hsu
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Article
| Open AccessBioinformatics analysis of prognostic value and immunological role of MeCP2 in pan-cancer
- Yanfeng Wang
- , Yunqing Zhang
- & Jing Zhang
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Article
| Open AccessA novel cuproptosis-related immune checkpoint gene signature identification and experimental validation in hepatocellular carcinoma
- Yusai Xie
- , Wei Zhang
- & Huiying Yu
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Article
| Open AccessCommon variability in oestrogen-related genes and pancreatic ductal adenocarcinoma risk in women
- Giulia Peduzzi
- , Livia Archibugi
- & Daniele Campa
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| Open AccessPotential mechanisms and prognostic model of eRNAs-regulated genes in stomach adenocarcinoma
- Liuying Gao
- & Hao Rong
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Article
| Open AccessTWIST1 induces proteasomal degradation of β-catenin during the differentiation of ovarian cancer stem-like cells
- Jiaqi Liu
- , Guang Shu
- & Gang Yin
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Editorial
| Open AccessGuest Edited Collection: Epigenetics within the tumor microenvironment
The tumor microenvironment (TME) comprises of components that exist within the immediate vicinity of tumor cells, including fibroblasts, immune cells, the extracellular matrix, and more. Significant advances have been made in recent years in our understanding of the components of TME and their mutual interactions. Part of the focus of this research has been on epigenetic events, which are increasingly being recognized for their importance in gene regulation and cancer progression. The Collection represents the gradual growth in our understanding of the overall process of how cancer progresses, along with the factors that play a decisive role in this progression. It features studies conducted on models representing many different cancers, and includes mechanistic reports conducted using appropriate in vitro models, studies that analyzed human cancer patients-derived specimens, clinical trials and, additionally, studies involving bioinformatics, metabolomics, chemical libraries screening, next-generation sequencing, and single-cell analysis approaches.
- Aamir Ahmad
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Article
| Open AccessActivation of recombinational repair in Ewing sarcoma cells carrying EWS-FLI1 fusion gene by chromosome translocation
- Kazuhiro Tanaka
- , Keiji Suzuki
- & Shinya Oda
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| Open AccessPTPRD and CNTNAP2 as markers of tumor aggressiveness in oligodendrogliomas
- Kirsi J. Rautajoki
- , Serafiina Jaatinen
- & Matti Nykter
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Article
| Open AccessThe diagnostic value of has_circ_0006423 in non-small cell lung cancer and its role as a tumor suppressor gene that sponges miR-492
- Linwen Zhu
- , Lebo Sun
- & Guofeng Shao
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Article
| Open AccessReal-world evidence of the intrinsic limitations of PCR-based EGFR mutation assay in non-small cell lung cancer
- Chia-I Shen
- , Chi-Lu Chiang
- & Chao-Hua Chiu
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Article
| Open AccessRNA editing facilitates the enhanced production of neoantigens during the simultaneous administration of oxaliplatin and radiotherapy in colorectal cancer
- Yasuhiro Komatsu
- , Kunitoshi Shigeyasu
- & Toshiyoshi Fujiwara
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Article
| Open AccessExploring synthetic lethal network for the precision treatment of clear cell renal cell carcinoma
- Zhicheng Liu
- , Dongxu Lin
- & Zhenyu Xiao
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Article
| Open AccessExome sequencing revealed comparable frequencies of RNF43 and BRAF mutations in Middle Eastern colorectal cancer
- Abdul Khalid Siraj
- , Rong Bu
- & Khawla Sami Al-Kuraya
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Article
| Open AccessRemarkable immune and clinical value of novel ferroptosis-related genes in glioma
- Xiaoyan Gao
- , Jiazheng Zhao
- & Qiushi Zhang
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Article
| Open AccessExploiting gene dependency to inform drug development for multiple myeloma
- Molly Went
- , Phuc H. Hoang
- & Richard S. Houlston
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Article
| Open AccessAmplification of CDK4 and MDM2: a detailed study of a high-risk neuroblastoma subgroup
- Angela Martinez-Monleon
- , Hanna Kryh Öberg
- & Tommy Martinsson
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Article
| Open AccessIdentification and validation of a novel 16-gene prognostic signature for patients with breast cancer
- Zhenhua Zhong
- , Wenqiang Jiang
- & Fengfeng Fan
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Article
| Open AccessPAI-1 is a potential transcriptional silencer that supports bladder cancer cell activity
- Hideki Furuya
- , Yuka Sasaki
- & Charles J. Rosser
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Article
| Open AccessMutations in the miR-142 gene are not common in myeloproliferative neoplasms
- Paulina Galka-Marciniak
- , Zuzanna Kanduła
- & Piotr Kozlowski
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Article
| Open AccessA transcriptomic signature for prostate cancer relapse prediction identified from the differentially expressed genes between TP53 mutant and wild-type tumors
- Wensheng Zhang
- & Kun Zhang
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Article
| Open AccessAssociation between germline variants and somatic mutations in colorectal cancer
- Richard Barfield
- , Conghui Qu
- & Ulrike Peters
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Article
| Open AccessAn integrative pan-cancer analysis of molecular characteristics and oncogenic role of mitochondrial creatine kinase 1A (CKMT1A) in human tumors
- Mengjie Yang
- , Shuna Liu
- & Wenbin Deng
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Article
| Open AccessUtility of plasma circulating tumor DNA and tumor DNA profiles in head and neck squamous cell carcinoma
- Nobuyuki Chikuie
- , Yuji Urabe
- & Sachio Takeno
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Article
| Open AccessImpact of sweet, umami, and bitter taste receptor (TAS1R and TAS2R) genomic and expression alterations in solid tumors on survival
- Ryan M. Carey
- , TaeBeom Kim
- & Kevin T. Nead
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Article
| Open AccessIdentification and validation of a novel pyroptosis-related lncRNAs signature associated with prognosis and immune regulation of hepatocellular carcinoma
- Zeyu Zhang
- , Fada Xia
- & Qianhui Hong
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Article
| Open AccessApparent regional differences in the spectrum of BARD1 pathogenic variants in Spanish population and importance of copy number variants
- B. Benito-Sánchez
- , A. Barroso
- & A. Osorio
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Article
| Open AccessDistinct clinicopathological and genomic features in solid and basaloid adenoid cystic carcinoma of the breast
- Juan Ji
- , Fang Zhang
- & Qingsong Liu
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Article
| Open AccessIdentification of an autophagy-related gene signature for predicting prognosis and immune activity in pancreatic adenocarcinoma
- Jiang Deng
- , Qian Zhang
- & Yanyu Zhang
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Article
| Open AccessEvaluation of a seven gene mutational profile as a prognostic factor in a population-based study of clear cell renal cell carcinoma
- Jeroen A. A. van de Pol
- , Paranita Ferronika
- & Klaas Kok
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Article
| Open AccessMeiotic drive in chronic lymphocytic leukemia compared with other malignant blood disorders
- Viggo Jønsson
- , Haneef Awan
- & Geir Erland Tjønnfjord
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Article
| Open AccessmRNA–miRNA bipartite networks reconstruction in different tissues of bladder cancer based on gene co-expression network analysis
- Zahra Abedi
- , Habib MotieGhader
- & Ali Masoudi-Nejad
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Article
| Open AccessPatient demographics, clinicopathologic features, and outcomes in wild-type gastrointestinal stromal tumor: a national cohort analysis
- Tahsin M. Khan
- , Emily A. Verbus
- & Andrew M. Blakely
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Article
| Open AccessscTEM-seq: Single-cell analysis of transposable element methylation to link global epigenetic heterogeneity with transcriptional programs
- Kooper V. Hunt
- , Sean M. Burnard
- & Heather J. Lee
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Article
| Open AccessPPP6C, a serine-threonine phosphatase, regulates melanocyte differentiation and contributes to melanoma tumorigenesis through modulation of MITF activity
- Carolyn R. Maskin
- , Renuka Raman
- & Yariv Houvras
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Article
| Open AccessA clinically relevant heterozygous ATR mutation sensitizes colorectal cancer cells to replication stress
- Tom Egger
- , Benoît Bordignon
- & Arnaud Coquelle
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Article
| Open AccessEvaluation of 41 single nucleotide polymorphisms in canine diffuse large B-cell lymphomas using MassARRAY
- Sirintra Sirivisoot
- , Tanit Kasantikul
- & Anudep Rungsipipat
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Article
| Open AccessGenetic variant located on chromosome 17p12 contributes to prostate cancer onset and biochemical recurrence
- Anca Gabriela Pavel
- , Danae Stambouli
- & Catalin Baston
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Article
| Open AccessCharacterization of the Portuguese population diagnosed with retinoblastoma
- Guilherme Castela
- , Joana Providência
- & Miguel Castelo Branco
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Article
| Open AccessMutational analysis of driver genes defines the colorectal adenoma: in situ carcinoma transition
- Jiri Jungwirth
- , Marketa Urbanova
- & Veronika Vymetalkova
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Article
| Open AccessA gene signature consisting of ubiquitin ligases and deubiquitinating enzymes of SKP2 is associated with clinical outcome in breast cancer
- Lon W. R. Fong
- , Jangsoon Lee
- & Shuxing Zhang
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Article
| Open Accessbrca2-mutant zebrafish exhibit context- and tissue-dependent alterations in cell phenotypes and response to injury
- Vassili A. Kouprianov
- , Aubrie A. Selmek
- & Heather R. Shive
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Article
| Open AccessGermline sequence variants contributing to cancer susceptibility in South African breast cancer patients of African ancestry
- Dewald Eygelaar
- , Elizabeth J. van Rensburg
- & Fourie Joubert
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Article
| Open AccessGenome-wide association study identifies tumor anatomical site-specific risk variants for colorectal cancer survival
- Julia D. Labadie
- , Sevtap Savas
- & Polly A. Newcomb
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Article
| Open AccessMeta-analysis of whole-genome gene expression datasets assessing the effects of IDH1 and IDH2 mutations in isogenic disease models
- Hans-Juergen Schulten
- , Fatima Al-Adwani
- & Mohammed H. Al-Qahtani
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Article
| Open AccessComprehensive quantitative analysis of alternative splicing variants reveals the HNF1B mRNA splicing pattern in various tumour and non-tumour tissues
- Jan Hojny
- , Romana Michalkova
- & Ivana Struzinska
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Article
| Open AccessUncovering drug repurposing candidates for head and neck cancers: insights from systematic pharmacogenomics data analysis
- Annie Wai Yeeng Chai
- , Aik Choon Tan
- & Sok Ching Cheong
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Article
| Open AccessCircFOXM1 promotes proliferation and metastasis of hepatocellular carcinoma via regulating miR-1179/SPAG5 axis
- Gaoqing Wang
- , Yin Jiang
- & Yongfei Hua
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Article
| Open AccessApplication of droplet digital polymerase chain reaction of plasma methylated septin 9 on detection and early monitoring of colorectal cancer
- Zhi Yao Ma
- , Cherry Sze Yan Chan
- & Wai K. Leung