Featured
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Article
| Open Access
Benefits and harms of cervical screening, triage and treatment strategies in women living with HIV
A model evaluating cervical screening, triage and treatment strategies to prevent cervical cancer in women living with HIV in Tanzania provides evidence to support the World Health Organization’s recommendation of primary HPV testing starting at age 25 years with 3–5-year regular screening intervals.
- Michaela T. Hall
- , Kate T. Simms
- & Karen Canfell
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Correspondence |
BrainStorm: a multicenter international study to tackle CNS metastases in solid tumors
- Diogo Martins-Branco
- , Guilherme Nader-Marta
- & Nuria Kotecki
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Article
| Open Access
Subsequent female breast cancer risk associated with anthracycline chemotherapy for childhood cancer
In a pooled analysis of six international studies involving about 17,900 female survivors of childhood cancer, the use of doxorubicin was associated with a dose-dependent risk of subsequent breast cancer, irrespective of prior chest radiotherapy exposure.
- Yuehan Wang
- , Cécile M. Ronckers
- & Jeanette F. Winther
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Consensus Statement |
A joint international consensus statement for measuring quality of survival for patients with childhood cancer
The International Childhood Cancer Outcome Project group, involving survivors and other relevant stakeholders, develop a set of core outcomes to measure the quality of care for 17 types of childhood cancers.
- Rebecca J. van Kalsbeek
- , Melissa M. Hudson
- & Lisa Zwiers
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Article
| Open Access
A deep learning algorithm to predict risk of pancreatic cancer from disease trajectories
A deep learning algorithm using electronic health records from two large cohorts of patients predicts the risk of pancreatic cancer from pre-cancer disease trajectories up to 3 years in advance, showing promising performance in retrospective validation.
- Davide Placido
- , Bo Yuan
- & Chris Sander
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Article
| Open Access
Multiomic neuropathology improves diagnostic accuracy in pediatric neuro-oncology
The integration of DNA methylation profiling and targeted sequencing with neuropathology improves the diagnostic accuracy of central nervous system tumors in a population-based cohort of more than 1,200 newly diagnosed pediatric patients.
- Dominik Sturm
- , David Capper
- & David. T. W. Jones
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Research Highlight |
Alcohol consumption and cancer
Drinking patterns contribute substantially to cancer incidence, according to a global population-based study.
- Karen O’Leary
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Analysis |
Avoidable flaws in observational analyses: an application to statins and cancer
Explicitly emulating a target trial using real-world data can avoid common biases in observational studies.
- Barbra A. Dickerman
- , Xabier García-Albéniz
- & Miguel A. Hernán
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Article |
Somatic mutations precede acute myeloid leukemia years before diagnosis
Somatic mutations detected years before diagnosis increase the odds of development of acute myeloid leukemia in women.
- Pinkal Desai
- , Nuria Mencia-Trinchant
- & Duane C. Hassane
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Letter |
Elevation of circulating branched-chain amino acids is an early event in human pancreatic adenocarcinoma development
Elevated plasma levels of branched chain amino acids detected prior to pancreatic cancer diagnosis may result from whole body tissue breakdown occurring during the early stages of this disease.
- Jared R Mayers
- , Chen Wu
- & Brian M Wolpin
Polygenic risk scores, radiation treatment exposures and subsequent cancer risk in childhood cancer survivors
Largest genetic study of breast cancer in African Americans launched