Research Highlights |
Featured
-
-
Letter |
Orally delivered thioketal nanoparticles loaded with TNF-α–siRNA target inflammation and inhibit gene expression in the intestines
The oral delivery of small interfering RNA (siRNA) to diseased intestinal tissue is challenging because of the harsh environment created by gastrointestinal fluids and mucosa. Now, such delivery of siRNA to sites of intestinal inflammation is achieved using polythioketal nanoparticles and gene expression is successfully inhibited in the inflamed tissue.
- D. Scott Wilson
- , Guillaume Dalmasso
- & Niren Murthy
-
Article |
Multimeric small interfering ribonucleic acid for highly efficient sequence-specific gene silencing
Small interfering ribonucleic acid (siRNA) is used to silence genes and treat conditions such as human immunodeficiency virus. Safe and efficient delivery, however, is proving problematic. A new class of biologically active siRNA polyelectrolyte complexes based on chemically self-crosslinked siRNA is presented, which shows greatly enhanced gene-silencing efficiencies in vitro and in vivo without significantly eliciting an immune response.
- Hyejung Mok
- , Soo Hyeon Lee
- & Tae Gwan Park
