Nucleic-acid therapeutics articles within Nature Materials

Featured

• Editorial | 04 December 2023

  Life-saving vaccines awarded

  The fundamental discoveries that enabled the development of effective mRNA vaccines against COVID-19 were awarded with this year’s Nobel Prize in Medicine.

• Article | 14 June 2021

  Programmable icosahedral shell system for virus trapping

  Programmable triangular DNA blocks self-assemble into distinct icosahedral shells with specific geometry and apertures that can encapsulate viruses and decrease viral infection.

  • Christian Sigl
  • , Elena M. Willner
  •  & Hendrik Dietz

• Article | 07 December 2015

  Self-assembled RNA-triple-helix hydrogel scaffold for microRNA modulation in the tumour microenvironment

  Tissue-adhesive scaffolds made by the conjugation of RNA triple helices to dendrimers lead to ∼90% shrinkage of tumours two weeks after implantation in a triple-negative breast cancer mouse model.

  • João Conde
  • , Nuria Oliva
  •  & Natalie Artzi

• News & Views | 22 March 2012

  Loaded-up microsponges

  Self-assembled microsponges of hairpin RNA polymers achieve, with one thousand times lower concentration, the same degree of gene silencing in tumour-carrying mice as conventional nanoparticle-based siRNA delivery vehicles.

  • Wade W. Grabow
  •  & Luc Jaeger