Featured
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Research Highlight |
Fixing an ageing mutation
A study in Nature reports that adenine base editors can correct the mutation that causes Hutchinson–Gilford progeria syndrome in a mouse model of this disease, extending lifespan.
- Katharine H. Wrighton
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Review Article |
Towards quantitative and multiplexed in vivo functional cancer genomics
CRISPR–Cas genome editing and next-generation sequencing are driving advances in cancer modelling and functional cancer genomics. Their application to autochthonous mouse models of human cancer to generate and analyse multiplexed and/or combinatorial alterations in vivo is reviewed here.
- Ian P. Winters
- , Christopher W. Murray
- & Monte M. Winslow
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Review Article |
Adaptive evolution: evaluating empirical support for theoretical predictions
The theoretical principles of adaptive evolution are being put to the test in a growing range of species and populations, particularly with new sequencing technologies and high-throughput experimental methods making headway in this area.
- Carrie F. Olson-Manning
- , Maggie R. Wagner
- & Thomas Mitchell-Olds
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Review Article |
Rare and common variants: twenty arguments
This Review presents arguments for and against each of two main models for the genetic basis of complex traits. It concludes that the infinitesimal model is essentially correct, but that rare, large-effect alleles also make an essential contribution to disease risk.
- Greg Gibson
Human organs-on-chips for disease modelling, drug development and personalized medicine
Fishing for the ageing secret
Competitive behaviour of cancer mutations
Predictions across space and time