Bacterial secretion articles within Nature

Featured

  • Article
    | Open Access

    The Csu pili of the multidrug-resistant nosocomial pathogen Acinetobacter baumannii assemble into an ultrathin zigzag architecture secured by a clinch mechanism that provides the pilus with high mechanical stability and superelasticity.

    • Natalia Pakharukova
    • , Henri Malmi
    •  & Anton V. Zavialov

  • Article
    | Open Access

    A cryo-electron microscopy structure of the inner membrane complex of the ESX-5 type VII secretion system of Mycobacterium tuberculosis reveals an important role of interactions with MycP5 protease for complex integrity.

    • Catalin M. Bunduc
    • , Dirk Fahrenkamp
    •  & Thomas C. Marlovits

  • Article |

    An interbacterial defence strategy, involving clusters of immunity genes against toxins released by the type VI secretion system of the same or different species, is widespread among Bacteroides species, and transfer of these gene clusters confers resistance to toxins in vitro and in the mammalian gut.

    • Benjamin D. Ross
    • , Adrian J. Verster
    •  & Joseph D. Mougous

  • Article |

    A cryo-EM structure of a membrane-embedded core complex of the ESX-3/type VII secretion system from Mycobacterium smegmatis is reported, providing insights into the mechanisms by which virulence factors are secreted by these bacteria.

    • Nikolaos Famelis
    • , Angel Rivera-Calzada
    •  & Sebastian Geibel

  • Article |

    A combination of X-ray crystallography, electron microscopy, functional assays and time-lapse fluorescence microscopy shows that a protein of previously unknown function, TssA, forms a dodecameric complex that interacts with components of the tube and sheath of the type VI secretion system of bacteria, and that it primes and coordinates biogenesis of both the tail tube and the sheath.

    • Abdelrahim Zoued
    • , Eric Durand
    •  & Eric Cascales

  • Letter |

    Growth of a flagellum outside the bacterial cell proceeds by successive subunit acquisition from the cell export machinery to form a chain that is pulled to the flagellum tip, where subunit crystallization provides the entropic force to drive the process.

    • Lewis D. B. Evans
    • , Simon Poulter
    •  & Gillian M. Fraser

  • Article |

    The crystal structure of BamA, the central component of the β-barrel assembly machinery (BAM) complex, from N. gonorrhoeae and H. ducreyi is determined; the structure consists of an interior cavity capped by extracellular loops, an exterior rim with a narrowed hydrophobic surface and a lateral opening of the barrel domain, providing insight into a possible route for the insertion of β-barrel membrane proteins into the bacterial outer membrane.

    • Nicholas Noinaj
    • , Adam J. Kuszak
    •  & Susan K. Buchanan

  • Letter |

    An X-ray structure of bacterial type VI secretion system components reveals that PAAR family proteins bind at the tip of the VgrG spike, providing new insights into the mechanisms of type VI secretion; experiments using bacteria confirmed the importance of PAAR proteins.

    • Mikhail M. Shneider
    • , Sergey A. Buth
    •  & Petr G. Leiman

  • News & Views |

    New data suggest that the most recently discovered class of bacterial 'molecular syringes' inject proteins only across the outer membrane of target cells during interbacterial competition. See Article p.343

    • Peggy Cotter

  • Letter |

    The bacterium Shigella flexneri, which causes dysentery, infects the gastrointestinal tract. It uses a type III secretion system as a molecular syringe to inject virulence factors into host cells during infection. It is now suggested that varying oxygen availability during different phases of infection tightly regulates expression of the secretion system, as well as the secretion of virulence factors.

    • Benoit Marteyn
    • , Nicholas P. West
    •  & Christoph M. Tang

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