Bacterial immune evasion articles within Nature

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  • Article |

    Antibiotic-resistant strains of Staphylococcus aureus, such as MRSA, are proving increasingly difficult to treat; here, one reason for this is confirmed to be the fact that S. aureus bacteria can reside in intracellular reservoirs where they are protected from antibiotics, but a new strategy—based on an antibody–antibiotic conjugate—can specifically target these reservoirs.

    • Sophie M. Lehar
    • , Thomas Pillow
    •  & Sanjeev Mariathasan

  • Letter |

    The structure of the Cas1–Cas2 complex bound to a protospacer sequence illustrates how foreign DNA is captured and measured by bacterial proteins in preparation for integration into CRISPR loci.

    • James K. Nuñez
    • , Lucas B. Harrington
    •  & Jennifer A. Doudna

  • Article |

    A Staphylococcus aureus leukotoxin targets cells expressing the chemokine receptor CCR5, a mechanism for the specificity of leukotoxins towards different immune cells.

    • Francis Alonzo III
    • , Lina Kozhaya
    •  & Victor J. Torres

  • Article |

    Salmonella enterica serotype Typhimurium causes acute gut inflammation, which promotes the growth of the pathogen through unknown mechanisms. It is now shown that the reactive oxygen species generated during inflammation react with host-derived sulphur compounds to produce tetrathionate, which the pathogen uses as a terminal electron acceptor to support its growth. The ability to use tetrathionate provides the pathogen with a competitive advantage over bacteria that lack this property.

    • Sebastian E. Winter
    • , Parameth Thiennimitr
    •  & Andreas J. Bäumler

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