Breast cancer is the most common invasive cancer in women and the second leading cause of cancer death in women after lung cancer. Great strides have been made in treatment options and targeted therapies but research continues to further improve survival rate.

See what scientists world-wide have been citing and sharing. In this Web Focus we highlight a selection of articles from 2019, which top the list of the journal’s most cited and most shared (including press coverage, blogs, Twitter, Facebook and Weibo). They showcase the breadth of scope and coverage that the journal consistently delivers to its readers.

See what scientists world-wide have been citing and sharing. In this Web Focus we highlight a selection of articles from 2018 which top the list of the journal’s most cited and most shared (including press coverage, blogs, Twitter, Facebook and Weibo). They showcase the breadth of scope and coverage that the journal consistently delivers to its readers.

Our understanding of cancer as a multi-step disease including complex metabolic rearrangements and changes in metabolic pathways involved in signalling, energy production and biosynthetic processes.

Oncogene has published several articles that have helped change the landscape in brain tumor research. This collection exemplifies the progress in the field. Even though it is by no means exclusive, we believe that the chosen papers address fundamental questions in the biology of GBM, medulloblastoma and even meningioma, a common but previously understudied benign brain tumor.

We are very proud that Oncogene has become an important voice in the cancer immunology conversation and we are pleased to present our collection of recently published papers in the field. These include both cutting edge original research articles as well as timely review papers. They add new targets and an understanding of mechanisms to this incredibly exciting area of translational cancer therapeutics. We hope you enjoy this selection.

A web focus from Cell Death & Differentiation, Cell Death & Disease, Nature Immunology and Oncogene. We hope you enjoy this focus including work from the world's most recognized experts in the field of Necroptosis.

A Web Focus from European Journal of Human Genetics and Oncogene. Next generation sequencing is rapidly pervading all areas of Human genetics: improving speed, precision, and last but not least breadth of diagnostics; opening up new avenues of screening; are screening and testing still different or is there a confluence? In parallel, it profoundly affects basic biology discovery by unravelling mutation mechanisms and causes and consequences in gene regulation and what goes wrong in genetic disease and cancer. Besides many insights, the data deluge also brings questions: on how to handle this, internally and towards the patients; the role of geneticists in the process; how - and if - to integrate direct to consumer services; how to maintain a proper public-private balance to allow therapy development but avoid undue restrictions in data access. Follow the contributions to this debate in European Journal of Human Genetics and Oncogene.

The January 2012 special issue presents two important strategies for generating potent and lasting anti-tumor immunity. The first strategy is to subvert immune suppressive networks in the tumor microenvironment. The second strategy is to optimize conventional and anti-biological modalities to directly target tumor and adjacent tumor tissue, and mobilize and expand anti-tumor immunity in the tumor microenvironment which results in tumor eradication. Further background information on this important topic is available through the accompanying web focus which links to related articles from across Springer Nature.