Nature

Focus 01 January 2014

A cross-journal web focus on necroptosis

A web focus from Cell Death & Differentiation, Cell Death & Disease, Nature Immunology and Oncogene.

We hope you enjoy this focus including work from the world's most recognized experts in the field of Necroptosis.

From Cell Death & Differentiation

Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012
- L Galluzzi
- I Vitale
- G Kroemer
Review15 Jul 2011 Cell Death & Differentiation
Many stimuli pull the necrotic trigger, an overview
- N Vanlangenakker
- T Vanden Berghe
- P Vandenabeele
ReviewOpen Access11 Nov 2011 Cell Death & Differentiation
TRAIL induces necroptosis involving RIPK1/RIPK3-dependent PARP-1 activation
- S Jouan-Lanhouet
- M I Arshad
- M-T Dimanche-Boitrel
Original Paper20 Jul 2012 Cell Death & Differentiation
BID regulates AIF-mediated caspase-independent necroptosis by promoting BAX activation
- L Cabon
- P Galán-Malo
- S A Susin
Original Paper8 Jul 2011 Cell Death & Differentiation
cIAP1 and cIAP2 limit macrophage necroptosis by inhibiting Rip1 and Rip3 activation
- S McComb
- H H Cheung
- S Sad
Original Paper11 May 2012 Cell Death & Differentiation
Obatoclax (GX15-070) triggers necroptosis by promoting the assembly of the necrosome on autophagosomal membranes
- F Basit
- S Cristofanon
- S Fulda
Original Paper7 Jun 2013 Cell Death & Differentiation
Necrostatin-1 blocks both RIPK1 and IDO: consequences for the study of cell death in experimental disease models
- P Vandenabeele
- S Grootjans
- N Takahashi
Editorial30 Nov 2012 Cell Death & Differentiation
The flick of a switch: which death program to choose?
- P Vandenabeele
- G Melino
Editorial11 Jun 2012 Cell Death & Differentiation
A role for c-FLIP_L in the regulation of apoptosis, autophagy, and necroptosis in T lymphocytes
- M-X He
- Y-W He
Original Paper23 Nov 2012 Cell Death & Differentiation

From Cell Death & Disease

Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models
- N Takahashi
- L Duprez
- P Vandenabeele
Original ArticleOpen Access29 Nov 2012 Cell Death & Disease
A novel role for RIP1 kinase in mediating TNFα production
- D E Christofferson
- Y Li
- J Yuan
Original ArticleOpen Access14 Jun 2012 Cell Death & Disease
TNF can activate RIPK3 and cause programmed necrosis in the absence of RIPK1
- D M Moujalled
- W D Cook
- D L Vaux
Original ArticleOpen Access17 Jan 2013 Cell Death & Disease
AIF-mediated caspase-independent necroptosis requires ATM and DNA-PK-induced histone H2AX Ser139 phosphorylation
- M Baritaud
- L Cabon
- S A Susin
Original ArticleOpen Access13 Sep 2012 Cell Death & Disease
Caspase blockade induces RIP3-mediated programmed necrosis in Toll-like receptor-activated microglia
- S J Kim
- Jianrong Li
Original ArticleOpen Access11 Jul 2013 Cell Death & Disease
Smac mimetic and demethylating agents synergistically trigger cell death in acute myeloid leukemia cells and overcome apoptosis resistance by inducing necroptosis
- L Steinhart
- K Belz
- S Fulda
Original ArticleOpen Access12 Sep 2013 Cell Death & Disease
Eleostearic acid induces RIP1-mediated atypical apoptosis in a kinase-independent manner via ERK phosphorylation, ROS generation and mitochondrial dysfunction
- S Obitsu
- K Sakata
- K Kondo
Original ArticleOpen Access20 Jun 2013 Cell Death & Disease
Copy number aberrations of BCL2 and CDKN2A/B identified by array-CGH in thymic epithelial tumors
- I Petrini
- P S Meltzer
- G Giaccone
Original ArticleOpen Access19 Jul 2012 Cell Death & Disease
Resistance to hypoxia-induced necroptosis is conferred by glycolytic pyruvate scavenging of mitochondrial superoxide in colorectal cancer cells
- C-Y Huang
- W-T Kuo
- L C H Yu
Original ArticleOpen Access2 May 2013 Cell Death & Disease

From Nature Immunology

Type I interferon induces necroptosis in macrophages during infection with Salmonella enterica serovar Typhimurium

The role of type I interferon in bacterial infection is poorly understood. Sad and colleagues demonstrate that Salmonella-triggered production of type I interferon induces macrophage necroptosis, evasion of the immune response and dissemination of bacteria.
- Nirmal Robinson
- Scott McComb
- Subash Sad
Article26 Aug 2012 Nature Immunology
Programmed necrosis: backup to and competitor with apoptosis in the immune system
- Jiahuai Han
- Chuan-Qi Zhong
- Duan-Wu Zhang
Review Article16 Nov 2011 Nature Immunology

From Oncogene

New frontiers in promoting tumour cell death: targeting apoptosis, necroptosis and autophagy
- J S Long
- K M Ryan
Review6 Feb 2012 Oncogene
A JNK-mediated autophagy pathway that triggers c-IAP degradation and necroptosis for anticancer chemotherapy
- W He
- Q Wang
- Y Lin
Original Article8 Jul 2013 Oncogene
Plk1 is upregulated in androgen-insensitive prostate cancer cells and its inhibition leads to necroptosis
- A Deeraksa
- J Pan
- L-y Yu-Lee
Original Article13 Aug 2012 Oncogene
Shikonin and its analogs inhibit cancer cell glycolysis by targeting tumor pyruvate kinase-M2
- J Chen
- J Xie
- X Hu
Original Article25 Apr 2011 Oncogene
Minor cell-death defects but reduced tumor latency in mice lacking the BH3-only proteins Bad and Bmf
- F Baumgartner
- C Woess
- A Villunger
Original Article19 Mar 2012 Oncogene
HSP-90 inhibitor ganetespib is synergistic with doxorubicin in small cell lung cancer
- C-H Lai
- K-S Park
- G Giaccone
Original Article28 Oct 2013 Oncogene

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