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CANCER IMMUNOLOGY
The January 2012 special issue presents two important strategies for generating potent and lasting anti-tumor immunity. The first strategy is to subvert immune suppressive networks in the tumor microenvironment. The second strategy is to optimize conventional and anti-biological modalities to directly target tumor and adjacent tumor tissue, and mobilize and expand anti-tumor immunity in the tumor microenvironment which results in tumor eradication. Further background information on this important topic is available through the accompanying web focus which links to related articles from across Springer Nature.
Reviews
Programmed necrosis: backup to and competitor with apoptosis in the immune system
Jiahuai Han, Chuan-Qi Zhong & Duan-Wu Zhang
Nature Immunology 12, 1143-1149 doi:10.1038/ni.2159
Tumor angiogenesis: molecular pathways and therapeutic targets
Sara M Weis & David A Cheresh
Nature Medicine 17, 1359-1370 doi:10.1038/nm.2537
Targeted therapies: how personal should we go?
Miriam Martini, Loredana Vecchione, Salvatore Siena, Sabine Tejpar & Alberto Bardelli
Nature Reviews Clinical Oncology doi:10.1038/nrclinonc.2011.164
Peptidoglycan recognition proteins: modulators of the microbiome and inflammation
Julien Royet, Dipika Gupta & Roman Dziarski
Nature Reviews Immunology 11, 837-851 doi:10.1038/nri3089
Letters
Dendritic cells control lymphocyte entry to lymph nodes through high endothelial venules
Christine Moussion & Jean-Philippe Girard
Nature 479, 542-546 doi:10.1038/nature10540
Nuclear factor-κB1 controls the functional maturation of dendritic cells and prevents the activation of autoreactive T cells
Dilan Dissanayake, Håkan Hall, Nancy Berg-Brown, Alisha R Elford, Sara R Hamilton, Kiichi Murakami, Leslie Summers Deluca, Jennifer L Gommerman & Pamela S Ohashi1
Nature Medicine 17, 1663-1667 doi:10.1038/nm.2556
Senescence surveillance of pre-malignant hepatocytes limits liver cancer development
Tae-Won Kang, Tetyana Yevsa, Norman Woller, Lisa Hoenicke, Torsten Wuestefeld, Daniel Dauch, Anja Hohmeyer, Marcus Gereke, Ramona Rudalska, Anna Potapova, Marcus Iken, Mihael Vucur, Siegfried Weiss, Mathias Heikenwalder, Sadaf Khan, Jesus Gil, Dunja Bruder, Michael Manns, Peter Schirmacher, Frank Tacke, Michael Ott, Tom Luedde, Thomas Longerich, Stefan Kubicka & Lars Zender
Nature 479, 547-551 doi:10.1038/nature10599
A novel recurrent mutation in MITF predisposes to familial and sporadic melanoma
Satoru Yokoyama, Susan L. Woods, Glen M. Boyle, Lauren G. Aoude, Stuart MacGregor, Victoria Zismann, Michael Gartside, Anne E. Cust, Rizwan Haq, Mark Harland, John C. Taylor, David L. Duffy, Kelly Holohan, Ken Dutton-Regester, Jane M. Palmer, Vanessa Bonazzi, Mitchell S. Stark, Judith Symmons, Matthew H. Law, Christopher Schmidt, Cathy Lanagan, Linda O'Connor, Elizabeth A. Holland, Helen Schmid, Judith A. Maskiell, Jodie Jetann, Megan Ferguson, Mark A. Jenkins, Richard F. Kefford, GrahamG. Giles, Bruce K.Armstrong, Joanne F. Aitken, John L. Hopper, David C. Whiteman, Paul D. Pharoah, Douglas F. Easton, Alison M. Dunning, Julia A. Newton-Bishop, Grant W. Montgomery, Nicholas G. Martin, Graham J. Mann, D. Timothy Bishop, Hensin Tsao, Jeffrey M. Trent, David E. Fisher, Nicholas K. Hayward & Kevin M. Brown
Nature 480, 99-103 (01 December 2011) doi:10.1038/nature10630
Original Article
Identification of germline susceptibility loci in ETV6-RUNX1-rearranged childhood acute lymphoblastic leukemia
FREEE Ellinghaus, M Stanulla, G Richter, D Ellinghaus, G te Kronnie, G Cario, G Cazzaniga, M Horstmann, R Panzer Grümayer, H Cavé, J Trka, O Cinek, A Teigler-Schlegel, A ElSharawy, R Häsler, A Nebel, B Meissner, T Bartram, F Lescai, C Franceschi, M Giordan, P Nürnberg, B Heinzow, M Zimmermann, S Schreiber, M Schrappe & A Franke
Leukemia doi:10.1038/leu.2011.302
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