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Three-dimensional structures for the INK4 proteins should reveal how the plethora of p16INK4a mutations found in human tumors might alter its function as a cyclin-dependent kinase inhibitor.
The crystal structure of the catalytic domain of adenylyl cyclase in complex with its activator Gsα suggests a surprising allosteric mechanism of activation by formation of a new catalytic site at the interface between conserved dimers of the soluble adenylyl cyclase domains.
The reversible spiral twisting of the flagellar propeller arises from combinations of interconvertible left- and right-tilted arrays of identical flagellin subunits, mediated by the restraints of their inner tube domains in 11 near-axial protofilament strands of different length in the flagellum.
Recent crystal structures of DNA polymerases provide new insights into conformational dynamics and DNA minor groove interactions that are critical for efficient and accurate DNA synthesis.
