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Volume 12 Issue 5, May 2005

Metaphase chromosomes from Chinese hamster ovary (CHO) cells were cultured in 5-Bromo-2'deoxyuridine (Br-dU) for two cell cycles and stained to reflect differential incorporation of the base analog. Sister Chromatid Exchanges (SCEs) are easily visualized as reciprocal exchanges in fluorescent intensity along the chromosome arms. Kindly provided by J. Corcoran and W. Morgan. pp 403-407; News and Views pp 392-393.

Volume 12 Issue 5

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Editorial

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News & Views

  • Work presented in this issue reveals the structure of a SNARE transmembrane domain and supports a model of exocytosis via hemifusion. Hemifusion may thus be a common intermediate in many, if not all, biological fusion reactions.

    • Judith M White
    • J David Castle
    News & Views

  • A key to understanding bacterial pathogenicity is the mechanism by which water-soluble protein toxins assemble on cell membranes to form oligomeric bilayer-spanning pores. The recent reconstructions from cryo-electron micrographs of three-dimensional pore and prepore structures of the cholesterol-dependent toxin pneumolysin shed new light on the later steps of the assembly of large toxin pores.

    • Hagan Bayley
    • Lakmal Jayasinghe
    • Mark Wallace
    News & Views

  • Two recent reports describe potentially novel therapeutic approaches for treating tumors arising from mutations in the tumor suppressor genes BRCA1 and BRCA2. These studies support the idea that selective killing of tumor cells can be achieved by targeting a specific DNA repair pathway on which an individual tumor type has become dependent.

    • Keith W Caldecott
    • Anthony Chalmers
    News & Views

  • A recent study reveals that the eukaryotic ribosomal protein L30 binds to the selenocysteine recoding RNA element and may function to tether the recoding machinery to the translating ribosome.

    • Marla J Berry
    News & Views

  • A new study shows that CtBP, a transcription corepressor, may mediate its effect by blocking histone acetylation, a mark of active transcription. This activity is modulated by NADH binding, thereby supporting a link between cellular metabolism and gene expression.

    • Erwan Lejeune
    • Andreas G Ladurner
    News & Views

  • The Mre11 protein complex plays important roles in maintaining genome stability. Inter-molecular bridging by the Rad50 protein has now been shown to be critical to this complex's function.

    • Michael Lichten
    News & Views
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