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Hitting transcription in all the right places

Nature Structural & Molecular Biology volume 12, pages 390–392 (2005)Cite this article

A new study shows that CtBP, a transcription corepressor, may mediate its effect by blocking histone acetylation, a mark of active transcription. This activity is modulated by NADH binding, thereby supporting a link between cellular metabolism and gene expression.

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Figure 1: The transcriptional corepressor CtBP associates with a variety of repressive activities and is regulated by cellular NADH levels.

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Acknowledgements

E.L. is supported by an E-STAR fellowship funded by the European Commission's FP6 Marie Curie Host fellowship for Early Stage Research Training and is a student in the European Molecular Biology Laboratory International PhD program.

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  1. Gene Expression Unit and Structural & Computational Biology Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, Heidelberg, 69117, Germany

    Erwan Lejeune & Andreas G Ladurner

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  1. Erwan Lejeune
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  2. Andreas G Ladurner
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Lejeune, E., Ladurner, A. Hitting transcription in all the right places. Nat Struct Mol Biol 12, 390–392 (2005). https://doi.org/10.1038/nsmb0505-390

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