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The structure of γδ resolvase complexed with a DNA cleavage site provides new insights into how resolvase accomplishes site-specific DNA recombination.
Amino-acid sequence comparison and tertiary structure modelling suggest a structure for type I DNA methyltransferases and an evolutionary link to type II DNA methyltransferases.
Structural analysis reveals mechanisms of drug resistance to HIV-1 protease inhibitors. These results have implications for the design of drugs and therapeutic strategies to combat drug resistance in AIDS.
Proteins that interact with RNA are now yielding to high-resolution structural analysis and these studies are going hand-in-hand with dissection of the RNA processing machinery of the spliceosome.