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Inflammatory arthritis

All fibroblasts are equal, but some are more equal than others

Nature Reviews Rheumatology volume 20, pages 254–255 (2024)Cite this article

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Characteristic patterns of joint involvement exist in different forms of arthritis. Research now indicates that epigenetic programming of synovial fibroblasts diversifies their response to inflammatory cascades, leading to this anatomical variation in arthritis and its response to treatment.

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Fig. 1: The long non-coding RNA HOTAIR governs joint-specific differences in inflammatory responses.

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Authors and Affiliations

  1. Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK

    Chrissy Bolton

  2. Rheumatology Research Group, Queen Elizabeth Hospital, University of Birmingham, Birmingham, UK

    Chrissy Bolton & Adam P. Croft

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  1. Chrissy Bolton
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  2. Adam P. Croft
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Correspondence to Adam P. Croft.

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The authors declare no competing interests.

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Bolton, C., Croft, A.P. All fibroblasts are equal, but some are more equal than others. Nat Rev Rheumatol 20, 254–255 (2024). https://doi.org/10.1038/s41584-024-01097-6

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