Research Highlights

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  • IKKε, an upstream regulator of the NF-κB signalling pathway, mediates cartilage degradation in a mouse model of osteoarthritis and is a potential therapeutic target.

    • Jessica McHugh
    Research Highlight
  • New research suggests that impaired synovial lymphatic function contributes to the pathogenesis of age-related osteoarthritis and could represent a new therapeutic target.

    • Sarah Onuora
    Research Highlight
  • A calcium-binding peptide derived from fetuin-A inhibited pathological cartilage calcification in an experimental model of osteoarthritis, suggesting therapeutic potential.

    • Sarah Onuora
    Research Highlight
  • New evidence from animal models and human studies suggests that mammalian target of rapamycin has a role in the pathophysiology of Still’s disease and macrophage activation syndrome.

    • Sarah Onuora
    Research Highlight
  • New research reveals that ferritin has an essential role in neutrophil extracellular trap (NET)-mediated inflammation, and suggests that NETs or the ferritin receptor MSR1 could be targeted for the treatment of adult-onset Still disease.

    • Sarah Onuora
    Research Highlight
  • A novel strategy for the repair of articular cartilage involves converting fibrocartilage to hyaline cartilage by modifying the cytoskeleton of fibrotic chondrocytes.

    • Sarah Onuora
    Research Highlight
  • An analysis of blood gene-expression signatures in patients with systemic lupus erythematosus has identified several patterns of expression, some of which are associated with disease activity and features such as the response to rituximab.

    • Robert Phillips
    Research Highlight
  • Targeting inhibitor of apoptosis proteins (IAPs) ameliorates experimental ANCA-associated vasculitis, by enhancing fatty acid oxidation in neutrophils.

    • Sarah Onuora
    Research Highlight
  • New research suggests that A20 expressed in fibroblasts protects against fibrosis (whereas its negative regulator downstream regulatory element antagonist modulator (DREAM) promotes fibrosis), and highlights the therapeutic potential of targeting the A20–DREAM network.

    • Sarah Onuora
    Research Highlight
  • A gut bacterium found in people at risk of rheumatoid arthritis (RA) or with early RA is recognized by circulating autoantibodies, and is arthritogenic when it colonizes germ-free mice, suggesting a causal role in RA development.

    • Robert Phillips
    Research Highlight
  • New research demonstrates that unrestrained cutaneous growth of Staphylococcus aureus causes autoimmunity characteristic of systemic lupus erythematosus in mice.

    • Robert Phillips
    Research Highlight
  • Using a combination of various single-cell and immune profiling approaches, researchers have characterized the unique adaptive immune landscape of anti-melanoma differentiation-associated gene 5 antibody-positive (MDA5+) dermatomyositis.

    • Jessica McHugh
    Research Highlight