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IKKε, an upstream regulator of the NF-κB signalling pathway, mediates cartilage degradation in a mouse model of osteoarthritis and is a potential therapeutic target.
New research suggests that impaired synovial lymphatic function contributes to the pathogenesis of age-related osteoarthritis and could represent a new therapeutic target.
A calcium-binding peptide derived from fetuin-A inhibited pathological cartilage calcification in an experimental model of osteoarthritis, suggesting therapeutic potential.
Lipid nanoparticles loaded with type II collagen and rapamycin can induce antigen-specific regulatory T cell responses and alleviate disease in a mouse model of osteoarthritis.
New evidence from animal models and human studies suggests that mammalian target of rapamycin has a role in the pathophysiology of Still’s disease and macrophage activation syndrome.
New research reveals that ferritin has an essential role in neutrophil extracellular trap (NET)-mediated inflammation, and suggests that NETs or the ferritin receptor MSR1 could be targeted for the treatment of adult-onset Still disease.
A novel strategy for the repair of articular cartilage involves converting fibrocartilage to hyaline cartilage by modifying the cytoskeleton of fibrotic chondrocytes.
An analysis of blood gene-expression signatures in patients with systemic lupus erythematosus has identified several patterns of expression, some of which are associated with disease activity and features such as the response to rituximab.
New research shows that combining a hydrogel with nanozymes to modify the hypoxic, inflammatory joint environment in rheumatoid arthritis enables stem cells to promote osseointegration.
The aryl hydrocarbon receptor (AhR) modulates the function of myeloid-derived suppressor cells (MDSCs) in a mouse model of Sjögren syndrome and is a potential therapeutic target.
New research suggests that A20 expressed in fibroblasts protects against fibrosis (whereas its negative regulator downstream regulatory element antagonist modulator (DREAM) promotes fibrosis), and highlights the therapeutic potential of targeting the A20–DREAM network.
A gut bacterium found in people at risk of rheumatoid arthritis (RA) or with early RA is recognized by circulating autoantibodies, and is arthritogenic when it colonizes germ-free mice, suggesting a causal role in RA development.
Inhibition of the DNA damage response kinase ATR prevents B cells from IFNα-mediated acquisition of a systemic lupus erythematosus immunogenic profile.
New research demonstrates that unrestrained cutaneous growth of Staphylococcus aureus causes autoimmunity characteristic of systemic lupus erythematosus in mice.
Using a combination of various single-cell and immune profiling approaches, researchers have characterized the unique adaptive immune landscape of anti-melanoma differentiation-associated gene 5 antibody-positive (MDA5+) dermatomyositis.
A new study demonstrates that a single-cell mass cytometry approach can provide a precise snapshot of how candidate drugs affect chondrocyte subpopulations from patients with osteoarthritis.
