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Antimalarial drugs have been used for many years to treat rheumatic diseases such as rheumatoid arthritis and systemic lupus erythematosus. This Viewpoint will discuss the recent advances in understanding the mechanisms of action of hydroxychloroquine and the possibility of establishing toll-like receptor signalling molecules as targets for new therapies.
Many forms of functional decline are preventable, treatable or manageable, but a screening tool that can identify frail or vulnerable patients is much needed. This Review describes the methods currently available for non-specialist evaluation of patients at risk of functional decline, including behavioral, interview and questionnaire assessments.