Articles in 2012

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  • Two new studies involving graph theoretical analysis of healthy brain connectivity show that in neurodegenerative diseases, pathology might spread across neural networks via transneuronal propagation.

    • Darran Yates
    Research Highlight
  • A growing body of evidence suggests that many psychiatric illnesses are associated with impaired mitochondrial function. Manji and colleagues review evidence from studies in animal models and humans and discuss strategies for therapeutics aimed at enhancing mitochondrial function in patients with psychiatric disorders.

    • Husseini Manji
    • Tadafumi Kato
    • Guang Chen
    Review Article
  • On the basis of data from brain network science, Bullmore and Sporns propose that brain organization is shaped by an economical trade-off between minimizing wiring cost and maximizing the efficiency of information transfer between neuronal populations and discuss this idea in the context of psychiatric and neurological disorders.

    • Ed Bullmore
    • Olaf Sporns
    Review Article
  • A dendritically targetedBdnfmRNA transcript is required for the regulation of food intake in response to leptin.

    • Katherine Whalley
    Research Highlight
  • Endoplasmic reticulum stress influences neurodegeneration in a mouse model of α-synucleinopathy.

    • Darran Yates
    Research Highlight
  • Sexual rejection inDrosophila melanogasterhas been found to reduce activity in the neuropeptide F reward pathway, resulting in compensatory enhanced ethanol consumption.

    • Sian Lewis
    Research Highlight
  • The representation of natural odours in the olfactory bulb is dense, not sparse.

    • Leonie Welberg
    Research Highlight
  • Newborn hippocampal granule cells are crucial in pattern separation, whereas older granule cells promote rapid pattern completion.

    • Leonie Welberg
    Research Highlight
  • Optogenetics enables the precise and targeted manipulation of the activity of specific neurons and is a powerful tool for the dissection of neural circuits. Tye and Deisseroth describe the latest refinements in optogenetic technology and show how this approach is being used to investigate the circuits involved in psychiatric and neurological disorders.

    • Kay M. Tye
    • Karl Deisseroth
    Review Article
  • The brain is a major target of insulin and insulin-like growth factors (IGFs). Fernandez and Torres-Alemán describe how these peptides enter the CNS to reach specific brain areas and review their actions in the developing and adult brain. They propose that insulin and IGFs regulate diverse processes that are all ultimately involved in energy homeostasis.

    • Ana M. Fernandez
    • Ignacio Torres-Alemán
    Review Article