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This study reports that the mitogen-activated protein kinase pathway controls plant tissue invasion by Magnaporthe oryzae through the control of hyphal constriction and the expression of effectors to suppress plant immunity.
A new study reports the discovery of 214 RNA viruses from diverse vertebrates that reveal new insights into host–virus relationships across evolutionary timescales.
This month’s Genome Watch discusses how a better understanding of the genetic mechanisms of antimalarial drug resistance can maximize the utility of genomic surveillance programs in informing the most effective drug policy.
In this Progress article, Collins and colleagues discuss how CRISPR-based analyses in genetically intractable microorganisms, including mycobacteria, fungi and parasites, have enabled the discovery of novel gene functions, the investigation of genetic interaction networks and the identification of virulence factors.
Autophagy is crucial for innate and adaptive antiviral immunity; in turn, viruses evade and subvert autophagy to support their replication and pathogenesis. In this Review, Choi, Bowman and Jung discuss the molecular mechanisms that govern autophagy during host–virus interactions.
Carriage of Streptococcus pneumoniae on the mucosa of the upper respiratory tract is the prerequisite for transmission and tissue invasion. In this Review, Weiser, Ferreira and Paton summarize the mechanisms that allow pneumococci to transmit and progress from colonizer to pathogen.
In recent years, several non-polio enteroviruses (NPEVs) have emerged as serious public health concerns. In this Review, van Kuppeveld and colleagues summarize recent insights from enterovirus research, with a special emphasis on NPEVs, and reflect on how recent discoveries may help in the development of new antiviral strategies.
Interactions among organisms are not limited to the exchange of electron donors. Most microorganisms are auxotrophs and thus rely on external nutrients for growth. In this Opinion article, Zengler and Zaramela postulate that auxotrophies and nutrient requirements among members of complex communities have profound implications for microbial interactions and thus the overall microbial network.
