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John Gunn and colleagues summarize recent progress in our understanding of the mechanisms of gall bladder infection bySalmonella enterica subsp. enterica serovar Typhi, in particular the mechanisms involved in S. Typhi biofilm formation on gallstones.
The composition of the human microbiota at various body sites can become altered following injury, infection and antibiotic treatment. In this Review, Gregor Reid and colleagues describe how a healthy microbiota can be restored, either naturally or aided by probiotic treatment, following such challenge.
A recent paper inMolecular Microbiology sheds new light on the involvement of MxiC in the regulation of secretion through the Shigella flexneritype III secretion system.
Recent outbreaks involving multidrug-resistant bacteria have prompted governments to alter the regulations governing antibiotic sales. By combining the new regulations with calls for new drug development and dispensing regimes, can antibiotic resistance be managed?
Translation fidelity is a highly regulated event in the cell. Reynolds, Lazazzera and Ibba describe the steps which ensure that the correct amino acid is incorporated in a nascent polypeptide, and discuss how changes in the translational fidelity can be beneficial for the cell.