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Volume 12 Issue 9, September 2011

From The Editors

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Research Highlight

  • Two groups provide insights into the subcellular events that initiate tissue morphogenesis.

    • Alison Schuldt
    Research Highlight
  • A novel role for ERK signalling in the regulation of PDH flux.

    • Joanna E. Huddleston
    Research Highlight
  • Brain sparing during starvation is mediated by ALK.

    • Rachel David
    Research Highlight
  • Identification of a signalling platform that can trigger apoptosis and necroptosis.

    • Katharine H. Wrighton
    Research Highlight
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In Brief

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Research Highlight

  • The replication checkpoint may release chromatin from the nuclear periphery.

    • Alison Schuldt
    Research Highlight
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In Brief

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Research Highlight

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Addendum

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Research Highlight

  • The kinase activity of the JAK2 JH2 domain inhibits JAK2.

    • Kim Baumann
    Research Highlight
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Review Article

  • The coordinated control of endothelial cell behaviour is critical for blood vessel morphogenesis. Recent data reveal elaborate mechanisms that fine-tune key signalling pathways (such as the vascular endothelial growth factor and Notch pathways) to control endothelial cell behaviour during blood vessel sprouting (angiogenesis).

    • Shane P. Herbert
    • Didier Y. R. Stainier
    Review Article
  • Keratinocytes of the epidermis undergo several transformations as they differentiate and migrate outwards in the tissue to maintain epidermal homeostasis. Dynamic changes in adhesive junctions and the cytoskeleton of keratinocytes are a driving force in this morphogenesis.

    • Cory L. Simpson
    • Dipal M. Patel
    • Kathleen J. Green
    Review Article
  • During mammary gland development, signalling networks between epithelial cells and several cell types in the stroma are orchestrated together with mechanical cues and collective cell migration events to drive morphogenesis.

    • Nikolce Gjorevski
    • Celeste M. Nelson
    Review Article
  • Four models have been proposed to explain growth control mediated by the morphogen Decapentaplegic in the fly imaginal disc. Recent findings have allowed a more careful evaluation of these models and may offer insights into morphogenetic growth control in other systems.

    • Ortrud Wartlick
    • Peer Mumcu
    • Marcos Gonzalez-Gaitan
    Review Article
  • Ubiquitylation regulates essentially all of the intracellular processes in eukaryotes by modifying numerous cellular proteins in a spatially and temporally controlled manner. Many components of the ubiquitin–proteasome system are themselves modified by ubiquitylation; this regulates their activity or targets them for degradation.

    • Allan M. Weissman
    • Nitzan Shabek
    • Aaron Ciechanover
    Review Article
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