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Volume 12 Issue 10, October 2011

From The Editors

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Research Highlight

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Structure Watch

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Research Highlight

  • RNF8 promotes the fusion of uncapped telomeres through ubiquitylation.

    • Rachel David
    Research Highlight
  • Repo-Man has a role in both chromatin remodelling and nuclear envelope reformation.

    • Antony F. Bickenson
    Research Highlight
  • Anin vitrosystem shows the C-terminal tail of CENPA is sufficient for centromere assembly.

    • Joanna E. Huddleston
    Research Highlight
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In Brief

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Research Highlight

  • ER contact with mitochondria positions mitochondrial constriction and fission.

    • Alison Schuldt
    Research Highlight
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Review Article

  • The ability of methylarginine sites to serve as binding motifs for Tudor proteins, and the functional significance of this, is now becoming clear. Tudor proteins are thought to interact with methylated PIWI proteins and regulate the PIWI-interacting RNA pathway in the germ line.

    • Chen Chen
    • Timothy J. Nott
    • Tony Pawson
    Review Article
  • Haematopoietic stem cell function is tightly controlled to maintain haematopoietic homeostasis, in part by specialized cells and factors that constitute the haematopoietic 'niche'. Recent discoveries have engendered a new appreciation for the dynamic nature of the niche, identifying novel cellular and acellular niche components and uncovering fluctuations in their importance over time.

    • Leo D. Wang
    • Amy J. Wagers
    Review Article
  • In the past 10 years, great progress has been made in the development of fluorescent proteins, including green fluorescent protein (GFP) and GFP-like proteins. Using these proteins together with a range of techniques has furthered our understanding of protein movement and protein–protein interactions.

    • Atsushi Miyawaki
    Review Article
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Viewpoint

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Opinion

  • The phosphodiesterase autotaxin (ATX) produces the lipid mediator lysophosphatidic acid (LPA) to regulate diverse processes, including cell migration and proliferation. Studies of the structure of ATX may shed new light on how ATX recognizes its substrates and associates with the cell surface to promote specificity in LPA signalling.

    • Wouter H. Moolenaar
    • Anastassis Perrakis
    Opinion
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Timeline

  • This year marks the thirtieth anniversary since embryonic stem (ES) cells were first isolated from mouse blastocysts. In this Timeline, one of the scientists to isolate mouse ES cells in 1981 gives a personal account of the ideas that led to, and followed, this milestone.

    • Martin Evans
    Timeline
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Erratum

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