News & Comment

James Olzmann discusses the groundbreaking work of Ron Kopito and colleagues, which demonstrated that a CFTR mutant is ubiquitinated and degraded by the cytosolic 26S proteasome. This discovery contributed to our understanding of ERAD and had important implications for the development of therapeutic agents for cystic fibrosis.

XIST loss causes partial gene reactivation at the inactive X chromosome, resulting in Mediator-dependent expansion of adult mammary stem cells and tumorigenesis.

Cail et al. introduce a platform to study the role of plasma membrane curvature during clathrin-mediated endocytosis.

Kate Meyer reminds us of a study of mRNA N⁶-methyladenosine that predated the epitranscriptomics era by decades.

H3K9me3 promotes imprinting in mouse embryos, including in a newly discovered type of imprinting control-like regions.

A Comment on the impact of improved protein structure prediction by Kathryn Tunyasuvunakool from DeepMind — the company behind AlphaFold.

Viegas and Figueiredo tell us how, among several molecular and biochemical discoveries, RNA trans-splicing was discovered in trypanosomes.

Mori et al. identify ATP and reactive oxygen species as key upstream cues for cell extrusion.

Progress in the characterization of new mRNA modifications has been slow. Fuks and colleagues explain why and offer potential solutions.

Heterochromatin DNA is heavily methylated yet also inaccessible. Olivier Mathieu describes the work that revealed how DNA methyltransferases access heterochromatin.

The transcription factor c-Maf is required for the specification of liver sinusoids and for the maintenance of a specialized sinusoidal network necessary for sustaining hepatocyte function.

Ma et al. show the role of CCT2, a chaperonin TRiC subunit, in aggrephagy, specifically in the removal of mature, solid-like protein aggregates.

Jane Skok recounts her journey back to academia after a 12-year-long career break.

The solid phase of oskar mRNA granules is required for proper Oskar protein synthesis and fruit fly development.

Arnold et al. document an alternative tricarboxylic acid cycle that takes place between the mitochondria and the cytosol and that can be adopted in specific cell states.

Transposons and their host genomes are entangled in an evolutionary arms race, recounts Tuğçe Aktaş.

The RNA-binding proteins RBGD2 and RBGD4 improve resistance to heat stress in plants by phase separating into heat-induced stress granules.

Ting and Lee describe how the trypanosome base J ‘inspired’ the discovery of the mechanism of active DNA demethylation.

Highly transcribed long genes ‘stiffen’ and form loops extending from the harbouring chromosomes.

Ma and Xu discuss the status, best practices and future of using deep learning methods to analyse single-cell data.