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Why novel mRNA modifications are so challenging and what we can do about it

Nature Reviews Molecular Cell Biology volume 23, pages 385–386 (2022)Cite this article

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The discovery of diverse chemical modifications of mRNA has spurred efforts to identify, map and characterize them. Yet aside from N6-methyladenosine (m6A), progress in epitranscriptomics has been stymied by discrepant data. Here we discuss the main obstacles in studying novel mRNA modifications and offer insights into how to surmount them.

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Authors and Affiliations

  1. Laboratory of Cancer Epigenetics, Faculty of Medicine, ULB-Cancer Research Centre (U-CRC), Université libre de Bruxelles, Institut Jules Bordet, Brussels, Belgium

    Audrey Penning, Jana Jeschke & François Fuks

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  1. Audrey Penning
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  2. Jana Jeschke
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  3. François Fuks
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Corresponding author

Correspondence to François Fuks.

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Competing interests

F.F. is a co-founder of EPICS Therapeutics (Gosselies, Belgium). The remaining authors declare no competing interests.

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Penning, A., Jeschke, J. & Fuks, F. Why novel mRNA modifications are so challenging and what we can do about it. Nat Rev Mol Cell Biol 23, 385–386 (2022). https://doi.org/10.1038/s41580-022-00485-8

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