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Stearic acid covalently binds to transferrin receptor protein 1 (TFR1) and inhibits TFR1–JNK signalling and E3 ubiquitin ligase HUWE1-mediated ubiquitylation of mitofusin, ensuring proper mitochondrial fusion and function.
The nascent polypeptide-associated complex (NAC) at the ribosome exit site contributes to correct targeting of nascent chains by determining whether MetAP or SRP associate with the ribosome.
Inhibition of mTOR by rapamycin attenuates the translation of interleukin-1α, thus reducing the secretion of inflammatory cytokines by senescent cells.
Transcription-blocking DNA lesions displace spliceosomes from chromatin and activate a non-canonical ataxia-telangiectasia mutated signalling pathway that modulates splicing.