Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Research Highlight
  • Published:

Cell cycle

Repurposing MYC and E2F in the absence of RB

Nature Reviews Molecular Cell Biology volume 16, pages 516–517 (2015)Cite this article

Subjects

in cells lacking the tumour suppressor protein RB, MYC and E2F1, E2F2 and E2F3 take part in an abnormal transcriptional programme

The transcription factors MYC and the E2F family members control cell proliferation in response to external cues, but the mechanisms behind this are not fully understood. A new study shows that, in wild-type cells, MYC and E2F1, E2F2 and E2F3 cooperate to promote progression through the S–G2 transition of the cell cycle, but only minimally affect the G1–S transition. However, in cells lacking the tumour suppressor protein RB, MYC and E2F1, E2F2 and E2F3 take part in an abnormal transcriptional programme that induces ectopic (premature) entry of cells into the S phase.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Liu, H. et al. Redeployment of Myc and E2f1–3 drives Rb-deficient cell cycles. Nat. Cell Biol. 17, 1036–1048 (2015)

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Temporary Acting Senior Editor, Nature Reviews,

    Joana Osorio

Authors
  1. Joana Osorio
    View author publications

    You can also search for this author in PubMed Google Scholar

Related links

Related links

Related links in Nature Research

Bertoli, C., Skotheim, J. M. & de Bruin, R. A. Control of cell cycle transcription during G1 and S phases. Nat. Rev. Mol. Cell Biol. 14, 518–528 (2013)

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Osorio, J. Repurposing MYC and E2F in the absence of RB. Nat Rev Mol Cell Biol 16, 516–517 (2015). https://doi.org/10.1038/nrm4044

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nrm4044

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing