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SIRT6-mediated deacetylation of H3K18ac is important for inhibiting pericentric transcription to prevent cellular defects associated with cancer and ageing.
Two new methods for nascent RNA sequencing show that, in yeast, splicing can occur surprisingly quickly following intron synthesis by RNA polymerase II.
Recognition of the innovative nature of the Beadle and Tatum experiment of mutation induction followed by selection has faded in the decades since; Bernard Strauss explains why.
Two new studies report the identification and comprehensive analysis of the m1A mRNA modification, showing that this mark is enriched at the 5′ UTRs of mRNAs and might have a functional role in promoting translation of methylated transcripts.
Lynne Maquat reminds us that almost 20 years before the discovery of microRNAs, an antisense regulatory RNA was identified in embryonic chick muscle cells.
J. B. Gurdon introduces this Focus issue by discussing the importance of the discovery of induced pluripotent stem cells 10 years ago and current challenges for the development of cell replacement therapies.
Advances in the derivation of pluripotent stem cells (PSCs) and their differentiation to specific cell types could have diverse clinical applications. Trounson and DeWitt provide an overview of the progress in using embryonic stem cell and induced PSC derivatives for disease treatment and discuss the potential and limitations of such approaches.
Sumoylation of MCM inhibits DNA replication initiation by counteracting the function of the kinases that activate MCM; the loss of MCM sumoylation coincides with origin firing.