Articles in 2013

M. lepraetriggers reprogramming of Schwann cells to promote its dissemination.

Spp1 recruits potential double-strand break sites to the repair machinery during meiosis.

A role for GPR161 in the basal repression of sonic hedgehog signalling.

miR394 signals from the protoderm to maintain stem cell activity at the shoot apex.

Both microRNAs (miRNAs) and other small non-coding RNAs (ncRNAs) are induced by DNA breaks and have been linked to the DNA damage response. This interplay between ncRNAs and repair factors may help to ensure efficient DNA repair and maintenance of genome stability.

The prevalence and physiological importance of alternative splicing in multicellular eukaryotes has led to increased interest in its control. Much has been learnt about how transcription and chromatin structure influence splicing events, as well as the effects of signalling pathways, and this understanding may hold promise for the development of gene therapies.

Identifies sites of Fzo1 ubiquitylation and DUBs that counteract this to influence mitochondrial fusion.

Amino acids are one of the key environmental stimuli signalling to mTOR. Although exactly how they are sensed and how they activate mTOR has remained elusive, a model has emerged that implicates signalling by RAG GTPases, Ragulator and v-ATPase at the lysosome and leucyl t-RNA synthetase in the cytoplasm.

Quiescent haematopoietic stem cells use glycolysis and switch to aerobic respiration for differentiation.

Caveolae in the plasma membrane mediate signalling control and the response to membrane stress. The roles of caveolins and cavins hold the key to caveola structure and function, and their dysfunction is linked to several human diseases.

The first edition of the textbookMolecular Biology of the Cellwas published in 1983. Its unique features and aim and the way it was written lie at the heart of its success.

Centralspindlin connects the mitotic spindle to the plasma membrane during cytokinesis.

TET2 promotes the modification of histones byO-linked β-D-N-acetylglucosamine.

The class O forkhead box transcription factors (FOXOs) control diverse gene expression programmes and are themselves regulated by several post-translational mechanisms. A common principle of their many roles is the maintenance of tissue homeostasis in response to environmental changes.

Unicellular eukaryotes and mammalian germ cells and stem cells can maintain their telomere length through the action of telomerase. Insights into the mechanism by which telomerase is recruited to capped telomeres, and the individual contributions of telomere-associated proteins, highlight differences in this process between humans, budding yeast and fission yeast.