Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Research Highlight
  • Published:

Chromatin

TET2 keeps histones sweet

Nature Reviews Molecular Cell Biology volume 14, pages 64–65 (2013)Cite this article

Subjects

The authors used protein affinity purification and mass spectrometry to look for functional partners of TET proteins. They found that TET2 and TET3 associate with O-GlcNAc transferase (OGT), which is the enzyme that catalyses O-GlcNAcylation. Furthermore, using mouse embryonic stem (ES) cells that express TET2, the authors confirmed the OGT–TET2 interaction at the endogenous level.

TET2 seems to recruit OGT to chromatin

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

ORIGINAL RESEARCH PAPER

  1. Chen, Q. et al. TET2 promotes histone O-GlcNAcylation during gene transcription. Nature 09 Dec 2012 (doi:10.1038/nature11742)

FURTHER READING

  1. Hanover, J. A., Krause, M. W. & Love, D. C. Bittersweet memories: linking metabolism to epigenetics through O-GlcNAcylation. Nature Rev. Mol. Cell Biol. 13, 312–321 (2012)

    Article  CAS  Google Scholar 

Download references

Authors
  1. Katharine H. Wrighton
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Wrighton, K. TET2 keeps histones sweet. Nat Rev Mol Cell Biol 14, 64–65 (2013). https://doi.org/10.1038/nrm3511

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nrm3511

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing