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  • A unique feature of mitochondrial DNA function is the coupling of initiation of transcription with that of replication. Tan et al. discuss the choice between initiation of either process, and how mitochondrial DNA packaging into nucleoids controls its accessibility and function in human cells.

    • Benedict G. Tan
    • Claes M. Gustafsson
    • Maria Falkenberg
    Review Article
  • Iron homeostasis in animals is tightly controlled, and numerous cellular pathways regulate iron uptake, storage, metabolism and secretion. Recent findings provide new insights into the sensory systems that fine-tune iron homeostasis and explain how cellular and systemic iron fluxes intersect.

    • Bruno Galy
    • Marcus Conrad
    • Martina Muckenthaler
    Review Article
  • The mitochondrial proteome is highly complex, comprising ~1,000–1,500 proteins in mammals. Recent technological advances are now helping to refine the mitochondrial proteome and are assisting in characterizing mitochondrial protein functions, paving the way for better diagnosis and treatment of mitochondrial diseases.

    • Zakery N. Baker
    • Patrick Forny
    • David J. Pagliarini
  • Congratulations to John Jumper and Demis Hassabis for winning the 2023 Albert Lasker Basic Medical Research Award.

    • Paulina Strzyz
    Research Highlight
  • In this Tools of the Trade article, Sarah Paramore (from the Devenport and Nelson labs) discusses the use of mouse strains carrying genomic alterations in PCP genes and how they can increase our understanding of mammalian planar cell polarity.

    • Sarah V. Paramore
    Tools of the Trade
  • Antioxidants modulate the levels of reactive oxygen species to allow their physiological roles whilst minimizing the oxidative damage and pathology. The roles and mechanisms of antioxidants are complex and context-dependent, necessitating better understanding of their actions in vivo and warranting caution with their use as therapeutic agents.

    • Barry Halliwell
    Review Article
  • Forkhead box (FOXO) transcription factors are important mediators of cell stress responses, generally considered to preserve homeostasis and counteract ageing. However, FOXO-mediated mechanisms can also support the survival of cancer and other dysfunctional cells, thereby complicating the link between FOXOs and lifespan extension.

    • Maria J. Rodriguez-Colman
    • Tobias B. Dansen
    • Boudewijn. M. T. Burgering
    Review Article
  • The first study to show, in C. elegans, that sensory neurons have a role in lifespan regulation.

    • Patricija van Oosten-Hawle
    Journal Club
  • Antennapedia proteins were among the first proteins found to be exchanged intercellularly. This discovery by Alain Prochiantz and colleagues has inspired researchers of various backgrounds.

    • Jin Woo Kim
    Journal Club
  • In this Review, the authors outline the thermodynamic and kinetic principles of protein misfolding and amyloid formation. Mechanisms of toxicity are discussed, focusing on the effect of amyloid interactions with cellular components, and the association of aggregation with healthy ageing and pathology.

    • Nikolaos Louros
    • Joost Schymkowitz
    • Frederic Rousseau
    Review Article
  • Bulut-Karslıoğlu remembers the publication of two seminal papers that described bivalent chromatin and how this discovery continues to affect research to this day.

    • Aydan Bulut-Karslıoğlu
    Journal Club
  • To activate noncanonical LC3B lipidation and NLRP3 inflammasome formation, stimulator of interferon genes (STING) forms a proton channel in Golgi membranes.

    • Lisa Heinke
    Research Highlight
  • Anne West recounts the study that showed postnatal accumulation of non-CpG DNA methylation in neurons coinciding with postnatal synapse maturation, suggesting that it contributes to brain function.

    • Anne E. West
    Journal Club
  • In the amphibian axolotl, the kinase mTOR is hyper-sensitive and activates a protein synthesis response that is crucial for wound healing and tissue regeneration.

    • Eytan Zlotorynski
    Research Highlight
  • YAP and TAZ are transcription coactivators with key roles in development and regeneration as well as in cancer. Many of these roles are executed by YAP/TAZ activation in stem cells. This Review discusses how YAP/TAZ regulate stem cell biology, and considers potential applications of modulating YAP/TAZ in regenerative medicine and cancer therapy.

    • Jordan H. Driskill
    • Duojia Pan
    Review Article
  • Cutler and Vijg remind us of the publication that laid the foundation for genetic mutation theories of ageing.

    • Ronald Cutler
    • Jan Vijg
    Journal Club