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Liver transplantation is a rare occurrence in patients with cystic fibrosis, and there are limited data on the benefits of such intervention. A recent study examined the outcomes of this procedure in children and adults with cystic fibrosis, reporting that a significant survival benefit can be achieved despite extrahepatic factors.
A single-center study demonstrates that omitting pathologic examination of some resected diminutive polyps rarely changes management. These results are indicative of the overall innocuous nature of diminutive polyps, and reinforce the rationale underlying the use of alternative polypectomy strategies at CT colonography rather than universal polypectomy for the management of these lesions.
A recent study in a mouse model of colitis has demonstrated that interleukin (IL)-13, through inhibition of the mixed type 1 and type 17 T-helper cell inflammatory response, has a protective effect. The decoy receptor IL-13Rα2 inhibits this protective effect, suggesting blockade of IL-13Rα2 as a potential therapy for patients with IBD.
Uncertainty about the risks of medications for IBD during pregnancy is a challenge for clinicians and patients. A recent prospective cohort study suggests that women under medical care for their disease have few adverse events.
A recent study by Din et al. has demonstrated that a low dose of aspirin (75 mg per day) can decrease the incidence of colorectal cancer (CRC) after only 5 years of treatment. The study also shows that use of an NSAID before diagnosis of CRC does not improve survival.
Patients with IBD often believe that stress leads to increased disease activity and symptoms. The major problem with work in this area is that it relies on perception, which is notoriously difficult to quantify. However, a recent study provides evidence to support the possible effect of stress on IBD symptoms.
No approved vaccine is currently available against hepatitis E virus (HEV), which can cause acute hepatitis E. A large-scale phase III study involving more than 100,000 Chinese adults has reported that the recombinant HEV vaccine, HEV 239, prevented acute hepatitis E with a vaccine efficacy of 94–100%.
Noncardiac chest pain (NCCP) is a common condition; however, there are few treatment options for patients with NCCP. A study has recently investigated the potential benefit of using a serotonin–norepinephrine reuptake inhibitor (venlafaxine) to treat patients with functional chest pain, which is experienced by a subgroup of those with NCCP.
