Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
Strategies for assessing and modulating LDL-cholesterol levels are central to preventing coronary artery disease; however, there is currently a great deal of interest in the diagnostic measurement of lipoprotein subclasses, including apolipoprotein B100-containing particles. This Viewpoint examines LDL subclass analysis and asks whether this technique has any clinical relevance.
Pituitary lesions discovered incidentally during a radiologic procedure performed for another reason are common. Pituitary incidentalomas have an autopsy prevalence of approximately 10%. Cost-effective strategies are needed to identify the uncommon lesions likely to cause harm, while avoiding unnecessary risk (and expense) to the majority of individuals with benign incidentalomas.
Testosterone use as anabolic therapy is controversial. Here, meta-analyses show that testosterone increases skeletal muscle mass and strength in androgen-deficient young men, older men and men with chronic illness; these data provide a compelling rationale for the development of selective androgen receptor modulators that mimic testosterone's effects without its side effects.
Two of the genes underlying Kallmann syndrome have been identified. As detailed here, studies of mutations in these genes in human and animal models give insight into the pathogenesis of this syndrome and provide valuable information about the normal development of the reproductive and olfactory systems.
