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The debut of stem cell-derived islets in the clinic for glycaemic control in patients with type 1 diabetes mellitus has garnered much excitement. Ongoing research in this field guarantees to be transformative for modern treatment of diabetes mellitus.
Adipocytes have high levels of many components of the complement system. These components are involved in antimicrobial activities, but also have the potential to regulate the maintenance and turn-over of adipocytes under normal and pathophysiological conditions through positive and negative regulation of the membrane attack complex.