Articles in 2023

This Primer by Cordonnier and colleagues describes the epidemiology, aetiology, pathophysiology, diagnosis and treatment of intracerebral haemorrhage.

This PrimeView highlights the pathogenesis of monogenic diabetes, a group of predominantly early-onset disorders that are caused by single genetic alterations.

Monogenic diabetes encompasses forms of diabetes that result from a single pathogenic genetic alteration and usually have an early onset. This Primer gives an overview of the epidemiology, pathophysiology, diagnosis and treatment of these conditions, as well as patient quality of life and open research questions.

This PrimeView summarizes the pathophysiology of fetal alcohol spectrum disorders, a group of conditions that occur in children exposed prenatally to alcohol.

Fetal alcohol spectrum disorders (FASD) are characterized by neurodevelopmental impairment with or without facial dysmorphology, congenital anomalies and poor growth. This Primer discusses the epidemiology, pathophysiology, diagnosis and treatment of FASD.

This PrimeView highlights the diagnosis of pre-eclampsia and summarizes its epidemiology, pathophysiology and management. It accompanies the Primer on this topic by Dimitriadis and colleagues.

Pre-eclampsia is a life-threatening disease of pregnancy and a leading cause of maternal and neonatal morbidity and mortality. This Primer by Dimitriadis and colleagues summarizes the epidemiology, mechanisms, diagnosis and treatment of pre-eclampsia, and discusses patient quality of life and open research questions for this condition.

Current medical education propagates bias and power imbalances in medical institutions, which cascade into professional practices and organizations. To serve the needs of all, we need an understanding of how modern medicine was set up, the biases that are embedded in the structures of health care and strategies to transform those structures.

This PrimeView highlights the pathophysiology of medication overuse headache, a secondary headache disorder caused by overuse of acute headache medications by individuals with underlying headache disorders.

Medication overuse headache is a secondary headache disorder that occurs in those with a primary headache disorder (commonly tension-type headache or migraine). This Primer reviews the epidemiology, pathophysiology, diagnosis and treatment of medication overuse headache, and discusses how this disorder affects the quality of life of patients.

This PrimeView highlights the mechanisms of ichthyosis and summarizes its epidemiology, diagnosis and management. It accompanies the Primer on this topic by Gutiérrez-Cerrajero and colleagues.

The ichthyoses are a group of dermatological disorders characterized by generalized scaly, erythematous skin, accompanied by epidermal barrier function disruptions. This Primer by Gutiérrez-Cerrajero and colleagues summarizes the epidemiology, mechanisms, diagnosis and treatment of ichthyosis, and discusses patient quality of life and open research questions for this condition.

Sexual and gender minorities (SGM) experience negative attitudes, stigma, denial of care or low-quality care from health-care providers. Increased awareness and adequate training of health-care professionals and students are required to reduce biases and barriers to care for SGM people.