V. Summersby

Circular RNAs

A new chapter in cardiovascular biology

Latest Reviews

  • Review Article |

    By stimulating the His–Purkinje network directly, His bundle pacing results in synchronized, physiological ventricular activation, which might improve clinical outcomes compared with the use of right ventricular apical pacing. Sharma and colleagues summarize early clinical observations, implantation techniques and outcome data with permanent His bundle pacing.

    • Parikshit S. Sharma
    • , Pugazhendhi Vijayaraman
    •  & Kenneth A. Ellenbogen
  • Review Article |

    The role of aspirin for the primary prevention of cardiovascular disease is controversial. In this Review, Patrono and Baigent discuss the new randomized trials on aspirin for the primary prevention of cardiovascular disease in the context of previous evidence, and appraise whether the new evidence is likely to enable a more targeted use of aspirin

    • Carlo Patrono
    •  & Colin Baigent
  • Review Article |

    In this Review, Mallat and colleagues critically evaluate the studies on the origin, fate and functions of vascular smooth muscle cells (VSMCs) in atherosclerosis, highlighting the importance of developmental origin, clonal expansion and plasticity of VSMCs cells in atherosclerosis and summarizing the roles of VSMCs and VSMC-derived cells in plaque development and progression.

    • Gemma L. Basatemur
    • , Helle F. Jørgensen
    • , Murray C. H. Clarke
    • , Martin R. Bennett
    •  & Ziad Mallat
  • Review Article |

    Neuromodulation therapy might be clinically useful in the management and prevention of lethal arrhythmias. In this Review, the authors discuss the neuroanatomical and neurophysiological basis for neuromodulation therapy, critically appraise the latest data on the clinical efficacy of this approach and highlight areas in the field of cardiac autonomic control that show the most promise for clinical translation.

    • Neil Herring
    • , Manish Kalla
    •  & David J. Paterson
  • Review Article |

    With the increase in the availability of RNA screening tools, numerous non-coding RNAs with important functions in the heart have been identified. In this Review, Lu and Thum discuss the non-coding RNA candidates with diagnostic and therapeutic potential in cardiovascular disease.

    • Dongchao Lu
    •  & Thomas Thum
  • Review Article |

    G protein-coupled receptor (GPCR) kinases (GRKs) can desensitize and downregulate GPCRs. In this Review, Pfleger and colleagues describe the changes in GPCR and GRK signalling in the heart under disease conditions and how GRKs can be targeted to treat heart failure.

    • Jessica Pfleger
    • , Kenneth Gresham
    •  & Walter J. Koch

News & Comment


Prevention of cardiovascular disease

V. Summersby

Prevention of cardiovascular disease

This Series features articles on the latest advances in the field of primary prevention, from lifestyle modification approaches to pharmacological and clinical interventions, to reduce the incidence of cardiovascular events.

Irene Fernandez-Ruiz


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