V. Summersby

Article Series | Epidemiology of cardiovascular disease

Latest Reviews

  • Review Article |

    Neuroimmune crosstalk has a potential role in the development and maintenance of arterial hypertension. Parati and colleagues discuss the interplay between the bone marrow, microglia and immune mediators, in particular through mechanisms involving cytokines and peptides, such as neuropeptide Y, substance P, angiotensin II and angiotensin-(1–7).

    • Laura Calvillo
    • , Mariela M. Gironacci
    • , Lia Crotti
    • , Pier Luigi Meroni
    •  & Gianfranco Parati
  • Review Article |

    Various models of cardiac arrhythmia have been developed in several different animal species to study the mechanisms of disease. In this Review, Clauss and colleagues summarize the advantages and disadvantages of the models and species used in arrhythmia research and provide guidance to investigators planning experiments in this field.

    • Sebastian Clauss
    • , Christina Bleyer
    • , Dominik Schüttler
    • , Philipp Tomsits
    • , Simone Renner
    • , Nikolai Klymiuk
    • , Reza Wakili
    • , Steffen Massberg
    • , Eckhard Wolf
    •  & Stefan Kääb
  • Review Article |

    Endothelin 1 is the most potent vasoconstrictor in the human cardiovascular system. In this Review, Dhaun and Webb discuss the biology of the endothelins and endothelin receptors and how these pathways can be therapeutically targeted in cardiovascular and renal diseases.

    • Neeraj Dhaun
    •  & David J. Webb
  • Review Article |

    In this Review, Berg and colleagues discuss how to maximize the likelihood of successful resuscitation after out-of-hospital cardiac arrest. The ‘chain of survival’ includes immediate recognition of cardiac arrest, early bystander cardiopulmonary resuscitation, rapid defibrillation, advanced emergency medical services and integrated post-cardiac arrest care.

    • David D. Berg
    • , Bentley J. Bobrow
    •  & Robert A. Berg
  • Review Article |

    Atherosclerosis is characterized by low-grade, chronic inflammation, and the balance between pro-inflammatory and inflammation-resolving mechanisms dictates the clinical outcomes. This Review discusses the specific causes of inflammation and the mechanisms underlying the impaired resolution of inflammation that characterize clinically dangerous atherosclerotic lesions and highlights the potential of pro-resolving mediator therapy for the prevention and treatment of atherosclerotic cardiovascular disease.

    • Magnus Bäck
    • , Arif Yurdagul Jr
    • , Ira Tabas
    • , Katariina Öörni
    •  & Petri T. Kovanen
  • Review Article |

    Many cardiovascular functions and the onset of adverse cardiovascular events are influenced by the circadian rhythm that exists in all cell types. In this Review, the authors summarize the role of the molecular clock in cardiovascular physiology and disease and suggest how circadian rhythms can be exploited, such as in chronotherapy, or targeted therapeutically.

    • Sandra Crnko
    • , Bastiaan C. Du Pré
    • , Joost P. G. Sluijter
    •  & Linda W. Van Laake

News & Comment

  • News & Views |

    Nonresolving inflammation underpins several prevalent diseases, including atherosclerosis and Alzheimer disease. The resolution of inflammation is an active process that tempers pro-inflammatory pathways and promotes tissue repair. Understanding the mechanisms that boost endogenous resolution is important for the design of new treatment strategies for nonresolving diseases.

    • Gabrielle Fredman
  • Research Highlight |

    Functional connectivity in the limbic system of the brain, which controls emotion and the autonomic system, is reduced in patients with Takotsubo syndrome compared with healthy individuals.

    • Gregory B. Lim
  • Research Highlight |

    The activin receptor type 2 (ACTRII) pathway is activated in ageing and heart failure (HF), and inhibition of this catabolic pathway is a potential therapeutic target for HF.

    • Gregory B. Lim
  • Research Highlight |

    A novel bioelectronic system that combines automated arrhythmia detection with optogenetic engineering for arrhythmia termination is able to stop atrial fibrillation without the need of electrical shock in a closed-chest experimental model.

    • Irene Fernández-Ruiz
  • Research Highlight |

    Singlet molecular oxygen generated by endothelial indoleamine 2,3-dioxygenase 1 has an important pathophysiological role in mammals in the redox regulation of arterial relaxation and blood pressure during inflammatory conditions through the formation of a tryptophan-derived metabolite

    • Irene Fernández-Ruiz


Prevention of cardiovascular disease

V. Summersby/Springer Nature Limited

Prevention of cardiovascular disease

This Series features articles on the latest advances in the field of primary prevention, from lifestyle modification approaches to pharmacological and clinical interventions, to reduce the incidence of cardiovascular events.

Irene Fernandez-Ruiz


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