Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Volume 7 Issue 6, June 2012

Nanoparticles can deliver a variety of cancer drugs directly into tumour cells, which increases the efficacy of the treatment while reducing side effects. Small interfering RNAs (siRNAs) have shown promise as therapeutic agents but it is difficult to get them into cells. Now Daniel Anderson and co-workers have demonstrated that self-assembled DNA nanoparticles can reliably deliver siRNAs into cells and silence target genes in tumours. As shown in this illustration, the DNA nanoparticles are tetrahedral in shape, with six protruding arms. DNA nanoparticles have a number of properties that are useful for drug-delivery applications: it is relatively easy to control their size and to bind either drug molecules or targeting ligands to them.

Letters p389; News & Views p344

IMAGE: HYUKJIN LEE

COVER DESIGN: ALEX WING

Research Highlights

Top of page ⤴

News & Views

  • A bioengineered thin film of M13 bacteriophage shows piezoelectric properties that are promising for small-scale device integration.

    • S. Michael Yu
    News & Views
  • Precisely engineered DNA nanostructures can be used to deliver small interfering RNA molecules into cells and tumours to suppress genes.

    • Dhiraj Bhatia
    • Saikat Chakraborty
    • Yamuna Krishnan
    News & Views
  • Repairing disordered blood vessels in tumours can improve the delivery of small nanomedicines.

    • Christopher J. Cheng
    • W. Mark Saltzman
    News & Views
  • The binding and unbinding of single proteins to a gold nanorod can be detected with the help of the surface plasmon resonance of the nanorod.

    • Mikael Käll
    News & Views
  • A hybrid photodetector unites the electronic properties of graphene with the optical properties of colloidal quantum dots to achieve high sensitivity.

    • Edward Sargent
    News & Views
Top of page ⤴

Letter

Top of page ⤴

Article

Top of page ⤴

Search

Quick links