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Single blood vessel analysis by artificial intelligence (AI) reveals heterogeneous vascular permeability among different tumour types, which is leveraged in rationally designing protein nanoparticle-based drug delivery systems to achieve active trans-endothelial permeability in tumours.
Combination of physical tissue expansion and super-resolution radial fluctuations achieves nanoscale resolution in pathology specimens with LED-based widefield microscopy.
An in-memory factorization device, based on a phase-change material, shows enhanced capabilities in solving large-scale factorization problems due to improved energy, area and time efficiencies of the memory function.
The n- and p-type channel characteristics of WSe2 are exploited to implement multiply–accumulate and activation functions simultaneously in an in-memory computing core.
High-Tc superconducting nanowire detectors can detect single photons of telecom wavelengths at a temperature of 25 K and may enable applications in quantum sensing and quantum information processing.
Biodegradable polylactic acid (PLA) microplastics are shown to undergo enzymatic hydrolysis by lipases found in the human gut to generate PLA oligomers, which self-aggregate to form nanoplastic particles. The oligomers and their nanoparticles bioaccumulated in multiple organs of a mouse model and caused acute intestinal inflammation.
Polymer-based nanomedicines have been engineered to ratiometrically deliver three different drugs to tumors, thereby bridging in vitro–in vivo correlation and producing synergistic therapeutic efficacy in multiple myeloma mouse models.
A technique that blends micro- and nanometre-scale printed elements has been used to sculpture white light into a spatial array of coloured twisted beams, demonstrating sophisticated photonic control even with common incoherent sources of light.
An electric field gradient can be used to control spin qubits in silicon quantum dots, enabling switchable fast single-qubit gates and, potentially, scalability.
The self-assembly of a triblock bottlebrush polymer at one length scale controls the ordering of the self-assembly at a smaller scale, forming a hierarchical unit cell.
