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PEGylated liposomal accumulation in inflamed regions has mainly been attributed to the enhanced permeation and retention effect. An arthritis model that chemotactically attracted myeloid cells shows that monocytes and neutrophils play an essential role in liposome delivery towards inflamed joints.
A sudden inversion of the supercurrent diode effect is revealed in both inductance and critical current measurements in ballistic Josephson junctions. A simple analytical model shows that the inversion is associated with a ground state jump, the elusive 0−π-like transition.
Crossing the blood–brain barrier in primates is a major obstacle to gene delivery in the brain. Here an adeno-associated virus variant (AAV.CAP-Mac) is identified and demonstrated for crossing the blood–brain barrier and delivering gene sequences to the brain of different non-human primates species.
By controlling the current and measuring the voltage via the fibre, a hybrid electronic–photonic sensor consisting of a p–i–n junction located on the fibre-tip junction can be used as an electrical sensor with optical readout.
An engineered version of the mechanosensitive protein talin was used as a monomer in combination with a synthetic chemical crosslinker to form a hydrogel. This shock-absorbing material is shown to capture and preserve projectiles fired at 1.5 km s−1.
Colloidal quantum dots are a potential source of scalable single-photon emitters, but they typically exhibit broad emission linewidths. Proppe et al. show narrow-linewidth emission from heavy-metal-free InP/ZnSe/ZnS dots with coherence times of up to 250 ps.
Ru nanoparticles on HZSM-5 catalysed solvent- and hydrogen-free upcycling of high-density polyethylene into a separable distribution of linear (C1 to C6) and cyclic (C7 to C15) hydrocarbons.
A lipid nanoparticle (LNP) component—an adjuvant lipidoid—is developed to enhance the adjuvanticity of LNPs, which significantly increases the innate and adaptive responses of the COVID-19 mRNA vaccines with good tolerability in mice.
Lanthanide downshifting nanoparticles with tunable emissions in the NIR-IIb sub-window (1,500–1,700 nm) region are ideal for deep-tissue imaging. Biofunctionalized core–shell, cubic-phase thulium-based nanoprobes show the non-invasive imaging of murine cerebral vasculature and the tracking of single immune cells and their extravasation in an inflammatory microenvironment.
Ultrafast spectroscopy experiments demonstrate that graphene electrons can transfer energy directly to liquid water with no mediation from the crystal lattice as their collective plasmon oscillation excites water’s molecular charge fluctuations.
In single-molecule characterization, the near-infinite re-read capability on the same region of interest has the potential to unlock greater sensing capacity. A nanopore-based method, named scanning ion conductance spectroscopy, provides complete control over the translocation speed and nanopore position along a selected region and can detect a single 3 Å gap in a long strand of DNA.
The authors generate the Berry curvature dipole and valley-coupled spin photocurrent via interfacial symmetry engineering at the WSe2/SiP heterostructure, and can electrically tune such nonlinear optoelectronic phenomena via the gate bias.
Hydrostatic pressure is an underexplored tuning knob to study moiré systems. Here a MoS2/WSe2 heterostructure is compressed and the enhancement in the moiré potential strength is quantified via moiré-activated Raman modes.
A surface functionalization approach allows for preparing a nanostructured molecular protection layer, enabling stretchable polymer electronics that stably operate in physiological environments over 80 days.
Here the authors report the delivery of neurotransmitter-conjugated KCC2 agonist using a reactive oxygen species–responsive polymer nanoparticle that can cross the damaged blood–spinal cord barrier and significantly increase recovery after spinal cord injury in vivo.
Yeast cells are engineered to prepare multifunctional synthetic biofragments as nanoprobes, which allow multivalent interactions and optimal molecular orientation on material surfaces for the detection of emerging biomarkers in a range of sensor platforms.
A laser printing approach generates physical unclonable fluorescent patterns, made from simple sugar. These environmentally friendly and ultraviolet-stable materials can be applied as anti-counterfeiting labels.
Spin waves are excited in a thin film of bismuth-doped yttrium iron garnet using radio-frequency pulses and interact with magnetic domain walls. Pulses as short as 1 ns translate a domain wall over 15 µm distances, offering control over domain-wall dynamics.
Autonomous microfluidics with plasmonic hot electron injection accelerates colorimetric DNA/RNA amplification detection and rapid diagnosis of pathogens in patient samples on par with polymerase chain reaction.
Quantum emitters with strong and tunable coupling to breathing-mode phonons are observed in bilayer WSe2. The emission of each single photon heralds the creation of a phonon Fock state in the atomic-scale excitonic–optomechanical system.