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Bioelectronic interfacing with living tissues should match the biomechanical properties of biological materials to reduce damage to the tissues. Here, the authors present a fully viscoelastic microelectrode array composed of an alginate matrix and carbon-based nanomaterials encapsulated in a viscoelastic hydrogel for electrical stimulation and signal recording of heart and brain activities in vivo.
The application of stimulated-emission depletion (STED) microscopy for deep-tissue imaging in the near-infrared optical window is challenged by high cellular autofluorescence. Here the authors present a lanthanide nanoprobe whose electronic configuration enables long-term STED imaging with reduced background noise.
This Review presents the emerging understanding of the importance of the dynamic and evolving protein corona composition in mediating the fate, transport and biological identity of nanomaterials in the environment. Principles specific to the environment are presented, along with a perspective on next steps toward mechanistic and predictive insights for the next phase of eco-corona studies.
Persistent luminescence is a promising bioimaging technique that is not affected by background autofluorescence, but its in vivo application is challenged by the fact that the materials currently available are activated by high-energy light, with emission in the ultraviolet and visible spectral windows. In this paper the authors engineer X-ray activated, lanthanide-based nanoparticles with a tunable emission in the biologically relevant NIR-II spectral region, which allows high-contrast, multimodal in vivo deep-tissue organ imaging.
Van der Waals heterostructures serve as a platform for memory devices with ultra-fast writing speeds and non-volatile retention times, motivating their use in integrated circuits and systems.
Among the candidates for large-scale quantum computing devices, silicon-based spin qubits offer an outstanding nanofabrication capability for scaling-up. In an array of three spin qubits in silicon, high-fidelity state preparation and control enable the creation of a three-qubit Greenberger–Horne–Zeilinger state with 88% state fidelity.
A sustainable and biodegradable antiviral filtration membrane composed of amyloid nanofibrils made from food-grade milk proteins and iron oxyhydroxide nanoparticles can be used to trap a number of enveloped and non-enveloped viruses in water.
MoS2/hBN/graphene van der Waals heterostructures with a clean interface and optimized barrier height and gate coupling ratio enable the realization of ultrafast non-volatile flash memory.
This Review provides an overview of four platform technologies that are currently used in the clinic for delivery of nucleic acid therapeutics, describing their properties, discussing technical advancements that led to clinical approval, and highlighting examples of approved genetic drugs that make use of these technologies.
The challenge of assessing the scope and magnitude of risk from nanomaterials is urgent for society and ignoring risks could be detrimental for development. This challenge is bigger than the individual capacities on each side of the Atlantic, but effective cross-Atlantic collaboration can solve essential riddles about the use of nanomaterials.
The proposal of a FAIR-aligned Nanosafety Data Interface can advance findability, accessibility and interoperability across physicochemical, bio–nano interaction, human toxicity, omics, ecotoxicological and exposure data.
A class of biomimetic, helically folded pore-forming polymeric foldamers can serve as long-sought-after highly selective ultrafast water-conducting channels exceeding those of aquaporins with high water-over-monovalent-ion transport selectivity conferred by the modularly tunable hydrophobicity of the interior pore surface.
Standardization and interoperability of data for both the functional and environmental performance properties of nanomaterials is essential to accelerate sustainable design.
The combination of three techniques to study the cellular binding and uptake, and intracellular transformation of silver nanoparticles shows that despite considerable transformation, these silver nanoparticles can still be found in nanoparticulate form after a substantial amount of time.
