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Cryo-electron microscopy uncovers the interfacial failure mechanism of lithium metal anodes at the atomic scale, informing a F-rich solid-electrolyte interface design strategy for highly-reversible solid-state Li metal batteries.
The transition from a linear ‘take–make–dispose’ economy to a circular economy is gaining momentum. Although there are many opportunities for using nanotechnology to enable circularity, the knowledge gaps related to (eco-)toxicological hazards and the presence of nanomaterials in waste streams constitute significant challenges.
Superconducting diodes, which can operate without dissipation losses at low temperature, usually require a magnetic field to function. A well-designed multilayer device now shows a reversible, non-volatile superconducting diode effect.
Li-metal surfaces can be effectively protected against corrosion using fluoroethylene carbonate, leading to a conformal and stable solid–electrolyte interphase.
Cell heterogeneity might impact the delivery of lipid nanoparticles (LNPs) and efficacy of messenger RNA-based therapies in vivo. Here, the authors propose an approach to measure how various LNPs deliver DNA barcodes and mRNA to cells using single-cell RNA sequencing, providing a correlation between LNP uptake and the expression of specific genes that characterize cellular subtypes.
Information thermodynamics offers a route to measure how effectively a light-driven molecular machine converts energy from absorbed photons into pumped motion.
Nanoneedle start-ups are traversing the biotech valley of death — from fundamental university research into commercial development in advanced therapeutics and diagnostics. How can academics make the most of this opportunity?
A theoretical model captures the thermodynamic principles behind the functioning of an out-of-equilibrium photoactivated artificial molecular pump in a quantitative manner.
We will now explicitly ask reviewers to flag up to us and authors whether a simpler model or theory could explain the experimental data in a given manuscript.
This Perspective suggests a characterization cascade for nanoparticle-based vaccines that takes into consideration the complexity of the materials and of their immunomodulatory responses, providing a roadmap for the preclinical validation of potential vaccine candidates.
Nicotinamide adenine dinucleotide (NAD+) is an immune modulator that was suggested as a potential treatment for sepsis, but its in vivo benefits are contradictory and its low bioavailability as a free drug hampers potential clinical translation. Here the authors show that using a lipid-coated nanoparticle to deliver NAD+ to the cell cytosol can effectively replenish the intracellular content of NAD+ and reduce the extent of the inflammatory response in mouse models of sepsis.
Light harvesting in photosynthesis and photovoltaics may rely on quantum-coherent energy transfer, but experimental verification is hindered by the lossy nature of the molecular systems. Subnanometre-resolved electroluminescence spectroscopy now reveals wavelike intermolecular electronic energy transfer through quantum coherence in artificially constructed donor–acceptor heterodimers at the single-molecule level.
Nanostructured fibres with highly aligned and alternating crystalline and amorphous domains created from triblock copolymers exhibit excellent mechanical properties, multi-trigger actuation, high-performance contraction and on/off rotation.
A frequency filtering method can efficiently remove the autofluorescence background and light scattering during in vivo visible and near-infrared experiments.
