Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
Sequencing of gorilla- and chimpanzee-infecting Plasmodium species elucidates the evolutionary history of the Laverania subgenus and highlights features of the human-infecting Plasmodium falciparum species that enable parasite transmission in humans.
Quorum sensing (QS) is shown to control eukaryotic-specific behaviours. QS peptide Qsp1 plays a crucial role in the intercellular regulation of unisexual and bisexual reproduction in the ubiquitous fungal pathogen Cryptococcus neoformans.
The cryo-electron microscopy structure of the Dot–Icm apparatus from Legionella pneumophila reveals the formation of a complex between the ATPases DotB and DotO, which creates a channel at the base of the type IV secretion system that defines the route of substrate transfer.
A combination of metagenome, single-cell and transcriptome sequencing, enrichment cultures and microscopy of geothermal environments in Yellowstone National Park leads to the discovery of a new archaeal lineage, the Marsarchaeota.
Nutrient stress impacts the coordination of transcription and translation in Escherichia coli: N starvation limits translation and (p)ppGpp slows transcription elongation accordingly; and C starvation limits transcription, which is resolved using a translation-aid-transcription mechanism.
Human CD45 serves as a receptor for the Staphylococcus aureus Panton–Valentine leukocidin (PVL) F-component LukF-PV and contributes to the species specificity behind PVL intoxication of human immune cells.
Cross-neutralizing antibodies from human survivors of the West Africa Ebola outbreak target a conserved membrane-proximal region in the virus glycoprotein HR2–MPER, which can be used as an immunogen to elicit neutralizing antibodies in rabbits.
A murine diet high in microbiota-accessible carbohydrates (MACs) reduces Clostridium difficile colonization compared to a low-MAC diet, which is associated with changes in microbiota composition, short-chain fatty acid concentrations and inflammation.
The extracellular domain of the cell wall protein LtaS is an insulin-binding protein and mediates insulin resistance during Staphylococcus aureus infection.
Splenic CD169+ macrophages serve as an intracellular reservoir for Streptococcus pneumoniae replication and are a target for cell-penetrant antibiotic therapy to prevent septicaemia.
This study describes the development of a primate model for Crimean–Congo haemorrhagic fever, the first immunocompetent animal model, which will be instrumental in developing and testing medical countermeasures for this serious disease.
The Pseudomonasaeruginosa effector TseT is loaded into the type VI secretion system (T6SS) by the chaperone TecT. Interactions between the T6SS needle-tip protein PAAR and TecT disrupt binding between TecT and its co-chaperone, co-TecT, and promote binding of TseT to PAAR.
A systematic analysis of viral protein phosphorylation elucidates the signalling network of the vaccinia virus F10 kinase and H1 phosphatase, identifying new functions for the reversible phosphorylation of the I7 protease and A7 transcription factor.
Aminoglycoside antibiotics administered topically are shown to induce a Toll-like-receptor-3-dependent interferon response mediated by XCR1+ dendritic cells that is unrelated to effects on the microbiota and can confer an antiviral state to the vaginal mucosa.
Characterization of xylan utilization loci in the butyrate-producing Firmicute Roseburiaintestinalis provides mechanistic insight into its growth on different xylan substrates and its ability to co-grow and compete with a xylan-degrading commensal from the Bacteroides genus.
Human haematopoietic progenitor cells are shown to be targets of human cytomegalovirus infection, which reprogrammes them into long-lived, highly immunosuppressive monocytes, initiating the establishment of latency through the STAT3–iNOS–NO axis.
A human challenge trial with Campylobacter jejuni uncovers transcriptional and genomic changes during infection, highlighting pathogen factors associated with acute and persistent infection.
Sand flies acquire Leishmania during blood meals. Subsequent blood meals, even from uninfected hosts, trigger dedifferentiation of non-replicating metacyclic promastigotes to a replicative form, termed the retroleptomonad promastigote, which amplifies parasite numbers in the flies.