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A citizen-science approach is used to map the vaginal microbiome of 3,345 women and identify associations with health, life-course and lifestyle factors.
Sperschneider et al. generate nuclear-assigned genome assemblies for several isolates of the wheat leaf rust pathogen, Puccinia triticina, and show that repeated nuclei shuffling between clonal lineages has created global populations.
The Plasmodium falciparum transcription factor PfAP2-P is an upstream regulator of parasite blood-stage development and regulates trophozoite development, host cell remodelling, antigenic variation and pathogenicity.
Human skin organoids are susceptible to mpox virus infection and support infectious virus production. Treatment of infected skin organoids with the antiviral drug tecovirimat can inhibit infectious virus production and prevent host transcriptome rewiring. Thus, skin-organoid-based models are robust for studying mpox virus infection and testing therapeutics.
Jimmy Nkaiwuatei is the Head of Research, Discovery and Innovations at Students Against Superbugs Africa, a youth-led organization tackling the problem of antimicrobial resistance through education and outreach in Africa.
Computational, molecular and structural analyses reveal the presence of bacterial histones that bind DNA to form dense, DNA-enveloping fibres in Bdellovibrio bacteriovorus.
Lactulose is used to treat patients with hepatic encephalopathy but this prebiotic can also increase intestinal Bifidobacteria, thereby reducing systemic infection, growth of multidrug-resistant bacteria and mortality that often accompanies chronic liver disease.
A multi-omics approach reveals that bifidobacteria metabolize the prebiotic lactulose to produce acetate and deconjugate bile acids, which is associated with reduced densities of drug-resistant pathogens and decreased incidences of infection in patients with liver disease.
Mpox virus productively infects human induced pluripotent stem cell-derived skin organoids and is inhibited by tecovirimat, revealing a model system for analysis of mpox virus pathogenesis and drug screening.
We used functional genomics to understand how hospital biocides impact the human pathogen Acinetobacter baumannii. Low concentrations of various biocides dissipated the membrane potential of A. baumannii, which we demonstrated could antagonize the potency of antibiotics.
Genomic fitness profiling of Acinetobacter baumannii treated with ten clinically relevant biocides using TraDIS reveals a common mechanism of action through dissipation of membrane potential that can promote antibiotic tolerance.
Computational, experimental and structural analyses reveal an abundant, nucleoid-associated histone and an alternative mode for DNA binding in vitro in the bacterium Bdellovibrio bacteriovorus.