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From metagenomics of Aedes mosquitoes from four continents, the authors analyse the mechanism by which insect-specific viruses affect mosquito vector competence to transmit dengue virus to humans.
The metavirome of 31 tick species sheds light on the diversity and distinct evolution of tick-associated RNA viruses, and lays the foundation for better understanding of tick–virus interaction.
Metabolic variation via a single substitution in the β-carbonic anhydrase CanB determines CO2 dependence and influences fluoroquinolone resistance in Neisseria gonorrhoeae.
The CRISPR–Cas9 system is widely studied for its role as a phage defence system and for gene editing applications, but its evolutionary origins are poorly understood. Here the authors use ancestral sequence reconstruction to determine the evolutionary history and ancient protein sequences of Streptococcus pyogenes Cas9 ancestors.
Head-to-head comparison of third doses of mRNA COVID-19 vaccines in US Veterans finds that both are effective against documented SARS-CoV-2 infection and severe COVID-19 outcomes.