Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
Bacteria can be engineered to degrade antibiotics in the gut, maintaining colonization resistance against pathogenic bacteria and constraining the expansion of antibiotic resistance genes in mice.
An analysis of memory T cells induced by messenger RNA vaccination reveals that they maintain polyfunctionality in response to the Omicron spike protein.
A machine learning framework for integrating multi-omic high-dimensional datasets identified disease-specific and shared host gene–microbiome associations across three gastrointestinal diseases.
A phenotypic screen based on a conditional Cas9-system identifies two Toxoplasma gondii genes, revealing conoid gliding protein (CGP) and signalling linking factor (SLF) that act at different steps in host cell egress.
Being a postdoctoral researcher opens many doors, but it can also bring feelings of loneliness and uncertainty, which are exacerbated during a pandemic. Making career choices that support and strengthen mental health should be normalized, writes Ann Gregory.
Understanding the mechanisms and evolution of pathogenicity in fungi will bring us a step closer to reducing the annual toll of 1.6 million deaths from fungal disease.
A comprehensive survey of secondary metabolites encoded in bacteria identifies large differences in biosynthetic diversity among genera and pinpoints those that can be targeted for novel chemistries provisionally suitable as antimicrobials.
The gut bacterium Clostridium sporogenes uses reductive Stickland reactions for energy and consequently produces metabolites that circulate in the host.
Multi-omics analyses of faecal, urine and blood samples from women with and without recurrent urinary tract infections reveal that gut dysbiosis and differential immune responses may play a role in risk of infection via the gut–bladder axis.
A comparison of the repertoire of SARS-CoV-2-specific epitopes targeted by T cells induced by vaccination or natural infection reveals that T cells predominantly target non-spike epitopes in convalescent individuals, while there is a broader spike-specific CD8+ T-cell response in vaccinees. Despite differences in T-cell response, the targeted T-cell epitopes were conserved between the wild-type and Omicron variants in both groups.
The development of a high-throughput tagging platform to screen kinases of the parasite Toxoplasma gondii led to the identification of a kinase regulating invasion of and egress from host cells.
A longitudinal analysis of viral expansion and clearance rates in 60 individuals sampled daily during acute infection reveals high inter-individual variation in infectious virus shedding, which may contribute to superspreading.
β-glucuronidases produced by gut microbiota members mediate proteolytic activity in the gut via the production of unconjugated bilirubin, which is dysregulated in irritable bowel syndrome.
An inhibitor of the SARS-CoV-2 main protease (Mpro), Y180, showed therapeutic efficacy against wild-type SARS-CoV-2 and its variants including Omicron after oral administration and improved survival in a humanized mouse model.