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MICROBIOME

Designed secretion deters microbiome depletion

Nature Microbiology volume 7, pages 745–746 (2022)Cite this article

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Bacteria can be engineered to degrade antibiotics in the gut, maintaining colonization resistance against pathogenic bacteria and constraining the expansion of antibiotic resistance genes in mice.

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Fig. 1: Lactococcus lactis spTEM1 degrades intestinal ampicillin to overcome the unintended consequences of antibiotics.

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Authors and Affiliations

  1. Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA, USA

    Christine A. Olson & Peter J. Turnbaugh

  2. Chan Zuckerberg Biohub, San Francisco, CA, USA

    Peter J. Turnbaugh

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  1. Christine A. Olson
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  2. Peter J. Turnbaugh
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Correspondence to Peter J. Turnbaugh.

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The authors declare no competing interests.

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Olson, C.A., Turnbaugh, P.J. Designed secretion deters microbiome depletion. Nat Microbiol 7, 745–746 (2022). https://doi.org/10.1038/s41564-022-01138-4

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