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Sub-surface microbial communities support methanogenesis via methylamine cycling and can persist by fermenting hydraulic fracture injection fluids. Microbial sulfide production contributes to reservoir souring and infrastructure corrosion.
By removing ambiguity and opacity in how we communicate with authors and by striving for timely and efficient handling of all manuscripts, Nature Microbiology is committed to providing a high-quality experience for all researchers submitting work for consideration, whether selected for publication or not.
Patients with atopic dermatitis have fundamentally different skin microbial populations compared with people with healthy skin. Bacteria associated with atopic dermatitis express genes for survival in dry conditions and for ammonia production, modulating the pH of this distinct environment and driving complex ecological interactions.
The global effect of human activities on Earth's microbiota has not yet been considered. Here, we identify potential trajectories of microbial change, and highlight knowledge gaps that need to be addressed to better understand how microbial communities across the globe will change in the future.
Accurate estimates of disease burden are possible by building high-resolution geographical models. However, novel pathogens such as Zika virus pose substantial challenges, requiring both new analytical techniques and, where possible, serological surveys.
Protein-synthesizing bacterial and archaeal cells can now be visualized by an adaptation of the BONCAT method, and sorted from complex samples for sequencing. A demonstration on the uncultivated, slow-growing methane-oxidizing consortia shows the high potential of this new method.
The mycobacterial glutamine amidotransferase GatCAB complex mediates the translational fidelity of glutamine and asparagine codons and strains with mutations in gatA show increased mistranslation, with associated antibiotic tolerance.
To coordinate cell wall synthesis, the fungus Ustilago maydis packages different cell-wall-forming enzymes into the same vesicles, which ensures that the enzymes travel together to foci of cell wall formation in the plasma membrane.
3D tracking of quantum dots, cross-kymography and computational modelling reveals a left-hand corkscrew motion of the H. salinarum archaellum, with a right-handed helical structure and a motor efficiency of 6–10%.
Transcriptional interactions between co-existing microorganisms from stool samples revealed enriched interactions involved in H2 and CO2 homeostasis, butyrate biosynthesis, ABC transporters, flagella assembly, bacterial chemotaxis and metabolism.
Termination sequencing reveals that several archaeal genes contain multiple consecutive-terminators, which results in the generation of alternative 3′ UTR isoforms during transcription, similar to what is observed in eukaryotes.
Pulsed doses of antibiotics increased the incidence of type 1 diabetes in non-obese diabetic (NOD) mice. This was associated with altered gut microbial composition, lipid metabolism, host cholesterol biosynthetic gene expression and Th17 and Treg cell proportions.
Treatment with lipid nanoparticles encapsulating siRNAs targeting the viral VP35 gene are able to rescue rhesus macaques infected with a lethal dose of Sudan ebolavirus.
Intracellular microsporidian parasites can restructure host cells to induce fusion with neighbouring cells, which enables cell-to-cell spread independent of spore formation.
Vaccinia virus recruits host proteins to promote viral release from infected cells. This is achieved by the viral protein A36, which contains three NPF motifs that interact with the host proteins intersectin-1 and Eps15.
Spatial correlation between microbial communities and chemical gradients within a lake system was observed, with few organisms capable of sulphate reduction, supporting microbial cooperation for geochemical functioning